MIF and autophagy： a novel link beyond ＂eating＂  

作　　者：Omar E1 Bounkari Jfirgen Bemhagen 

机构地区：[1]lnstitute of Biochemistry ＆ Molecular Cell Biology, RWTH Aachen University, Pauwelsstrasse 30, D-52074 Aachen, Germany

出　　处：《Cell Research》2012年第6期950-953,共4页细胞研究（英文版）

摘　　要：Macrophage migration inhibitory factor （MIF） is overexpressed in numerous tumors and has been correlated with the development of breast cancer, but the mechanism（s） have largely remained unknown. Suppression of autophagy has now been unraveled as a pivotal mechanism underlying MIF＇s role in breast cancer. Strikingly, the study demonstrates that MIF phenocopies the anti-autophagic effects of steroid receptor coactivator-3 （SRC-3）, a known oncogene, which in turn drives MIF gene expression.

关 键 词：自噬作用 MIF 链接 小说 基因表达 辅激活因子 过度表达 抑制因子 

分 类 号：Q959.116[生物学—动物学] TP311.52[自动化与计算机技术—计算机软件与理论]