五种抗生素联合应用对大肠杆菌抗菌效果实验  

Antibacterial Effect of Five Antibiotics Combined Application on Escherichia coli

作　　者：杜冬冬[1] 王涛[1] 常维山[1] 

机构地区：[1]山东农业大学动物科技学院,山东泰安271018

出　　处：《中国兽药杂志》2012年第6期14-16,共3页Chinese Journal of Veterinary Drug

摘　　要：研究亚胺培南与头孢曲松钠、亚胺培南与头孢噻肟钠、丁胺卡那与痢菌净在体外联合应用对于大肠杆菌ATCC25922的抗菌效果。测定各种药物对于大肠杆菌ATCC25922的最小抑菌浓度,应用棋盘微量稀释法测定亚胺培南与头孢曲松钠、亚胺培南与头孢噻肟钠、丁胺卡那与痢菌净对大肠杆菌ATCC25922的抑菌效果。结果显示,亚胺培南与头孢曲松钠、亚胺培南与头孢噻肟钠、丁胺卡那与痢菌净联合应用对大肠杆菌ATCC25922呈现协同作用。亚胺培南与头孢曲松钠、亚胺培南与头孢噻肟钠、丁胺卡那与痢菌净的联合应用大大减少了药物用量,提高了药物效果,为临床用药提供理论支持。The combined antibacterial effects of imipenem and ceftriaxone sodium, imipenem and cefotaxime sodium, amikacin and mequindox on Escherichia coli ATCC25922 in vitro were studied. Firstly the minimal inhibitory concentration of these medicines against Escherichia coli ATCC25922 was determined. The antibacterial effects of imipenem and ceftriaxone sodium, imipenem and eefotaxime sodium, amikaein and mequindox were determined by chessboard micro - dilution method. The results showed that the combined application of imipenem and ceftriaxone sodium, imipenem and cefotaxime sodium, amikaein and mequindox on Escherichia coli ATCC25922 had synergistic effect. The combined application of imipenem and ceftriaxone sodium, imipenem and eefotaxime sodium, amikacin and mequindox reduced dosage of the drugs and improved curative effect, the study provided theoretical support for clinical medication.

关 键 词：大肠杆菌 联合用药 棋盘微量稀释法 耐药性 

分 类 号：S852.61[农业科学—基础兽医学]