“道地综合指数”的构建及其应用价值  

Establishment of Dao-Di index and its significance in quality control and rational usage of Chinese medicine

作　　者：肖小河[1] 王伽伯[1] 鄢丹[1] 吕旸[1] 

机构地区：[1]解放军302医院全军中医药研究所,北京100039

出　　处：《中国中药杂志》2012年第11期1513-1516,共4页China Journal of Chinese Materia Medica

基　　金：国家杰出青年科学基金项目(30625042);国家中医药管理局公益性行业科研专项(200807020);国家"重大新药创制"科技重大专项(2009ZX09502-022)

摘　　要：现行中药品质评价控制指标众多,但大多数为定性的且彼此孤立,与安全性、有效性关联不紧密。该文首次提出构建基于产区相对历史、产地生态适宜性、商品规格等级、组分黄金比例和生物效(毒)价的中药材品质数字化一体化评价控制方法和指标体系(简称道地综合指数,DDI)。DDI指数有助于更全面、更客观、更有效地评价控制和保证中药材品质,有望发展成为真正具有中医药原创思想且行之有效的中药品质评价控制标准,同时对中药"品-质-性-效(毒)-用"一体化与临床合理用药等也将具有推动作用。There exists numerous indices for quality evaluation and control in Chinese medicinal materials. However, most of these indices are qualitative and non-interrelated each other, as well as having little relationship with safety and efficiency. In this arti- cle, we first establish a comprehensive evaluating index Dao-Di index （DDI） based on five factors ： relative history of producing ar- eas, ecological suitability of producing areas, commercial specification and grade, golden rate of main components, and biopotency/ toxic potency. This DDI can he used to guarantee the quality of Chinese medicinal materials more comprehensively, objectively and ef- fectively, promoting the integration of species-quality-property-effect-usage, and it will provide significant references and revelation for taking a world leading role of quality control standard for tranditional medicines.

关 键 词：道地综合指数 中药材 品质评价 合理用药 品-质-性-效-用一体化 

分 类 号：R282.5[医药卫生—中药学]