奥洛他定温度敏感眼用原位凝胶的制备  

Preparation of olopatadine in situ thermosensitive gel for ophthalmic use

作　　者：马凤余[1] 胡容峰[2] 徐亚静[2] 胡晓[2] 

机构地区：[1]安徽新华学院药学院,安徽合肥230088 [2]安徽中医学院药学院,安徽合肥230038

出　　处：《中国医院药学杂志》2012年第11期858-861,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研制奥洛他定温度敏感眼用原位凝胶。方法:采用泊洛沙姆P407和P188为温敏材料,以胶凝温度为指标,通过星点设计-效应面法优化处方。结果:经过优化筛选出的处方在室温条件下是自由流动的液体,在生理条件下发生胶凝形成凝胶。结论:所研制奥洛他定眼用温度敏感原位凝胶符合眼部应用要求,体现出良好的临床应用前景。OBJECTIVE To prepare olopatadine in situ thermosensitive gel for ophthalmic use. METHODS The olopatadine thermosensitive gel was prepared with poloxamer 407 and poloxamer 188 as thermosensitive material, the formulation was opti mized by central composite design-response surface method. RESULTS An optimized formulation was a freely flowing liquid at room temperature and converted to a firm gel in the physiological condition. CONCLUSION Olopatadine in situ thermosensitive gel accorded with the requirement for ophthalmic application and showed great potential in ophthalmic application.

关 键 词：奥洛他定 温度敏感 原位凝胶 制备 

分 类 号：R943[医药卫生—药剂学]