吗氯贝胺离子敏感型鼻用原位凝胶的制备及其体外释放度考察  

Preparation of moclobemide ion-sensitivity in situ gels and study on its drug release rate in vitro

作　　者：关玲玲[1] 张开莲[1] 

机构地区：[1]泸州医学院药学院,四川泸州646000

出　　处：《中国医院药学杂志》2012年第11期864-867,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备吗氯贝胺离子敏感型鼻用原位凝胶,并考察其体外释药行为。方法:以去乙酰结冷胶为凝胶基质,丙二醇、聚乙二醇-400及聚山梨酯-80为主要辅料,单因素试验法优选处方,并采用数学模型拟合体外释放曲线。结果:确定0.1%的结冷胶作为吗氯贝胺离子敏感型鼻用原位凝胶的基质,而体外释药行为符合Higuchi方程,该混合凝胶剂具有良好的体外缓释特征。结论:该处方设计合理,可作为经鼻给药的缓释载体。OBJECTIVE To prepare moclobemide ion-sensitivity in situ gels and to study the release mechanism in vitro. METHODS The formulations were selected by the application of gellan gum as the gel matrix. Propylene glycol,PEG-400 and Tween-80 were used as the main materials by the investigation of simple factor. The mathematical models were used to imitate the drug mechanism in vitro. RESULTS 0.1% gellan gum were suitable to moclohemide ion-sensitivity in situ gels. The dissolution curves in vitro showed that the drug release could be best described by the Higuchi equation. The mixed gel had a good characteristic of sustained-release. CONCLUSION The design of the formulation is reasonable and it is a suitable nasal delivery system for sustained-release.

关 键 词：吗氯贝胺 鼻用原位凝胶 鼻腔给药 体外释放度 

分 类 号：R94[医药卫生—药剂学]