清热解毒口服液在小鼠体内抗甲型流感病毒的实验研究  

Study on Qingre Jiedu oral liquid against influenza A virus in vivo

作　　者：王保宁[1] 张玉芬 任来峰[1] 左斌[1] 李婉宜[1] 蒋忠华[1] 李明远[1] 黄媛莉 

机构地区：[1]四川大学华西基础医学与法医学院,四川成都60041 [2]广元市朝天区疾病预防控制中心,四川广元628012 [3]四川好医生攀西药业有限公司,四川西昌615000

出　　处：《华西药学杂志》2012年第3期287-288,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的观察清热解毒口服液在BALB/c小鼠体内抗甲型流感病毒的作用。方法将BALB/c小鼠随机均分为正常对照组、流感病毒感染模型组、利巴韦林片组、连花清瘟胶囊组及清热解毒口服液高、中、低剂量组。小鼠感染流感病毒后ig给药,以生存情况、死亡保护率及延长生命率作为指标,观察清热解毒口服液抗流感病毒的作用。结果清热解毒口服液各剂量组均能减轻感染小鼠的发病症状;死亡保护率为50%～60%;延长生命率为61.56%～73.84%。与阳性药物利巴韦林片及连花清瘟胶囊比较,差异无统计学意义。结论清热解毒口服液在BALB/c小鼠体内有抗甲型H1N1流感病毒的作用,其机制有待深入研究。OBJECTIVE To observe the effect of Qingre Jiedu oral liquid（QJOL） against influenza A virus in BALB/c mice.METHODS BALB/c mice were divided into 7 groups,normal control,virus control,Ribavirin tablets,Lianhua Qingwen capsules（LQC）,high,middle and low dosage of QJOL.The FM1 infection model was established by dripping FM1 into nasal cavity and the appropriate treatments were prescribed.The effective anti-FM1 index of QJOL included survival status,protective percentage of death and life elongation percentage of mice infected with FM1.RESULTS All mice treated with QJOL could improve the general status of infection,decrease the death rate with death protective percentage form 50% to 60%,and prolong the survival time with life elongation percentages from 61.56% to 73.84%.There was no statistical significance between positive drugs Ribavirin tablets and LQC.CONCLUSION QJOL could resist influenza A virus in BALB/c mice significantly.The effect was the same between Ribavirin tablets and LQC.Further study is needed to understand its mechanism.

关 键 词：清热解毒口服液 体内实验 甲型流感病毒 BALB/C小鼠 

分 类 号：R96[医药卫生—药理学]