解脲支原体对中药有效部位的药敏试验研究  

Susceptibility testing on the effective part of Chinese medicine of Ureaplasma urealyticum

作　　者：沈黎明[1] 喻林冲[1] 

机构地区：[1]四川省医学科学院四川省人民医院皮肤病性病研究所,四川成都610031

出　　处：《华西药学杂志》2012年第3期294-295,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的探讨解脲支原体对中药有效部位体外的敏感性。方法应用微量稀释培养法,检测10种中药有效组分体外抗14株解脲支原体的敏感性。结果黄柏氯仿提取物最敏感,其MIC50为0.0625 mg·mL-1,MIC90为0.25 mg·mL-1,其次为大黄总蒽醌、栀子总苷和总甘草酸。结论中药有效部位对解脲支原体的敏感性较原生药水煎剂平均提高10倍以上。OBJECTIVE To study the sensitivity in vitro of Ureaplasma urealyticum（UU） on the effective part of Chinese medicine.METHODS The sensitivity of 10 kinds of the effective part of Chinese medicine on the anti-14 UU standard strains by microdilution culture methods.RESULTS The extractive of Cork chloroform is the most sensitive which MIC50 was 0.0625 mg·mL-1 and MIC90 was 0.25 mg·mL-1.Rhubarb,gardenia glycosides and total glycyrrhizic acid are consequently sensitive.CONCLUSION The sensitivity of the effective part of Chinese medicine to UU standard strains were more 10 times than the native medicine decoction.

关 键 词：中药有效组分 解脲支原体 微量稀释法 MIC 非淋菌性尿道炎 

分 类 号：R96[医药卫生—药理学]