毛冬青皂苷元ilexgenin A在大鼠体内的药动学研究  

Pharmacokinetic study of ilexgenin A in rats

作　　者：李美芬[1] 赵钟祥[1] 林朝展[1] 熊天琴[1] 迟玉广[1] 祝晨蔯[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《华西药学杂志》2012年第3期296-297,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:30901954);广东省自然科学基金资助项目(编号:9451040701003203);高等学校博士学科点专项科研基金(编号:20094425110008);广州市珠江科技新星专项(编号:2011J2200047)

摘　　要：目的探讨静脉给予ilexgenin A后大鼠体内的药物动力学特征。方法采用HPLC测定大鼠血浆中的血药浓度,用DAS 2.0药动学软件求算其药动学参数。结果 Ilexgenin A在大鼠体内呈二室模型分布,主要药动学参数为:t1/2α=0.545min,t1/2β=18.338 min,Cl=0.019 L·min-1.kg-1,AUC0→t=2.5902 g·min·L-1。结论所用方法可用于大鼠血浆中ilexgeninA的检测及其体内药动学研究;静脉给药后,ilexgenin A在大鼠体内分布和消除迅速。OBJECTIVE To study the pharmacokinetics of ilexgenin A in rats after intravenous injection.METHODS HPLC was used,and parameters of pharmacokinetics were calculated by DAS 2.0 software.RESULTS The blood plasma concentration-time course was fitted with 2-compartment model.The pharmacokinetic parameters were as following：t1/2α=0.545 min,t1/2β=18.338 min,Cl=0.019 L·min-1·kg-1,AUC0→t=2.5902 g·min·L-1.CONCLUSION The HPLC method is appropriate for the determination and pharmacokinetic study of ilexgenin A in rat plasma.Ilexgenin A is distributed and eliminated quickly in rats.

关 键 词：毛冬青 Ilexgenin A 大鼠 高效液相色谱 药物动力学 

分 类 号：R917[医药卫生—药物分析学]