聚甲基丙烯酸-介孔氧化硅复合材料的制备及释药性能  

Preparation and Drug Release Performance of Polymethacrylic Acid-Mesoporous Silica Composite

作　　者：郑晓谦[1] 周志平[1] 

机构地区：[1]江苏大学材料科学与工程学院,江苏镇江212013

出　　处：《精细化工》2012年第6期537-540,共4页Fine Chemicals

基　　金：国家自然科学基金资助(21174057)~~

摘　　要：采用自由基聚合的方法合成了pH敏感性聚甲基丙烯酸(PMAA)/介孔分子筛SBA-15纳米复合物。用XRD、FTIR、TG、低温N2吸附-脱附、TEM等对复合物进行了表征,并以阿司匹林为模型药物分子,进行了药物释放测试。结果表明,复合材料仍然保持有序六方结构,但比表面积、孔容、孔径有所降低;在pH=7.4的释放介质中,12 h内释放了72%的药物,而在pH=1.0的释放介质中,12 h药物释放量为30%。该纳米复合材料对阿司匹林的释放具有pH敏感性,有望在药物控制释放领域得到应用。The pH-sensitive mesoporous nanocomposite PMAA/SBA- 15 was synthesized by free radical polymerization. The nanoeomposite was characterized by means of X-ray diffraction, fouriertransform infrared spectroscopy, thermogravimetric analysis, transmission, N2 adsorption-desorption and electron microscopy. With aspirin as model drug, the drug release behavior of the composite was studied. It was found that the composite remained in an ordered hexagonal structure, but the surface area, the pore volume and the pore size o~ the composite decreased. In the release medium of pH = 7.4, the release of aspirin was much quicker than in that of pH = 1.0. Therefore, the release of aspirin from the nanocomposite could be controlled by changing the value of pH. The PMAA/SBA - 15 composite has a potential application in the field of drug release control.

关 键 词：PH敏感性 聚甲基丙烯酸 SBA-15 阿司匹林 控制释放 功能材料 

分 类 号：TB34[一般工业技术—材料科学与工程] TQ225[化学工程—有机化工]