半胱氨酰白三烯受体拮抗剂对脑缺血的保护作用  

Protective effects of cysteinyl leukotriene receptor antagonists on ischemic brain injury

作　　者：魏尔清[1] 

机构地区：[1]浙江大学医学院药理学系,杭州310058

出　　处：《中国新药杂志》2012年第11期1250-1254,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金项目(81072618)

摘　　要：炎症是影响脑缺血急性损伤严重程度以及慢性期恢复的主要因素之一,而半胱氨酰白三烯是体内最重要的炎症介质之一,通过半胱氨酰白三烯受体(CysLT1R和CysLT2R)调节脑缺血后炎症等病变。目前,已证实CysLT1R拮抗剂对脑缺血动物模型急性和亚急性/慢性损伤的保护作用,其神经元保护作用可能是间接通过调节胶质细胞,对星形胶质细胞增殖及胶质疤痕形成则有明确的抑制作用。CysLT2R拮抗剂还有待深入研究,但可能与神经元和星形胶质细胞损伤、小胶质细胞激活等有密切关系。CysLT1R和Cys-LT2R拮抗剂是抗脑缺血损伤潜在的新型治疗药物。Inflammation is one of the major factors impacting the severity of acute ischemic injury and the recovery in chronic phases after brain ischemia.Cysteinyl leukotrienes are the most important inflammatory mediators in the body,and play their regulatory roles in pathophysiological processes,such as post-ischemic inflammation,via activating their receptors（CysLT1R and CysLT2R）.Currently,it has been demonstrated that CysLT1R antagonists exert protective effects on acute and subacute/chronic injuries of the ischemic brain in animal models.The actions of neuronal protection may be indirectly mediated by modulating glial cells;however,the inhibition of astrocyte proliferation and glial scar formation has been proven.On the other hand,CysLT2R antagonists need further investigation,but they are closely related to neuronal and astrocyte injuries as well as microglial activation.CysLT1R and CysLT2R antagonists will represent potentially novel therapeutic drugs in the treatment of ischemic stroke.

关 键 词：半胱氨酰白三烯 受体 拮抗剂 脑缺血 炎症 

分 类 号：Q256[生物学—细胞生物学] Q421