1-脱氧野尻霉素对SAMP8小鼠感觉运动能力和体重的影响  

Effects of 1-deoxynojirimycin on sensorimotor ability and body weight in SAMP8 mice

作　　者：陶飞[1] 何燕[1] 杨启纲[1] 王芳[1] 陈勇平 陈贵海[1] 魏兆军[3] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]2.Department of Biomedical Engineering,Johns Hopkins University,baltimoremd21212 [3]合肥工业大学生物技术和食品工程学院,合肥230009

出　　处：《安徽农业大学学报》2012年第3期341-344,共4页Journal of Anhui Agricultural University

基　　金：安徽省高校省级自然科学重点项目(ZD2008007-1/2);安徽省自然科学基金项目(09020103001)共同资助

摘　　要：利用平衡木和紧绳任务检测长期口服桑叶提取物1-脱氧野尻霉素(DNJ)对SAMP8的体重和感觉运动能力的影响。结果显示,受DNJ处理小鼠的体重无显著性改变(与同龄空白对照组比较,P>0.05)。老年空白对照组平衡木和紧绳平衡时间显著短于青年组(Ps<0.05)。20 mg.kg-1.d-1DNJ组平衡木和紧绳平衡时间显著长于空白对照组(Ps<0.05);10 mg.kg-1.d-1DNJ组的紧绳平衡时间也显著长于空白对照组(P<0.05)。上述结果提示长期口服DNJ可以延缓SAMP8小鼠年龄相关性感觉运动能力减退,对体重无显著性影响。In this study, the effects of long-term orally administered, an extract of Mulberry leaves i.e., 1-deoxynojirimycin （DNJ）, on sensorimotor ability and body weight were explored in the SAMP 8 mice. The re- sults showed that DNJ treated mice had no significant difference in the body weight compared to the age-matched control mice （P〉0.05）. The elderly control mice had significantly shorter balance time than the young mice in the beam walking and tightrope tasks （Ps〈0.05）. However, the 20 mg.kg-l.d-1 DNJ treated mice had significantly longer balance time than the age-matched control mice in the both tasks, so had the l0 mg.kg-l-d-1 DNJ treated mice in the tightrope task. Our results indicated that long-term oral administration of DNJ does not affect body weight but can attenuate age-related sensorimotor ability decline in SAMP8 mice.

关 键 词：1-脱氧野尻霉素 小鼠 衰老 感觉运动 能力 体重 

分 类 号：S865.13[农业科学—野生动物驯养] R339.38[农业科学—畜牧兽医]