家兔挤压伤后心脏节段旋转功能评价的实验研究  

Experimental study on cardiac segmental rotation function of rabbits after crush injury

作　　者：赖小今[1] 廖明松[1] 郭进春[2] 陶杰[1] 邓旦[1] 梁燕[1] 陈重[1] 熊杰[3] 胡宗海[3] 李坤[4] 王超[4] 罗克枢[5] 

机构地区：[1]成都军区总医院超声科,成都610083 [2]成都军区总医院干部病房,成都610083 [3]成都军区总医院检验科,成都610083 [4]成都军区总医院中心实验科,成都610083 [5]成都军区总医院病理科,成都610083

出　　处：《西南国防医药》2012年第6期585-588,共4页Medical Journal of National Defending Forces in Southwest China

基　　金：四川省卫生厅基金课题(090009)

摘　　要：目的应用超声斑点追踪技术评价家兔挤压伤后的心脏收缩期节段旋转功能,评估挤压伤后心肌继发受损的情况。方法 42只新西兰家兔按标准制作挤压伤模型,随机分为对照组,解压即刻,解压后6、12、24、48、72 h共7组,每组6只,分别检测挤压前及解压后不同时间段左室收缩期节段旋转功能等情况。结果左室感兴趣区域的收缩期节段旋转功能在解压后12～24 h降至最低(P<0.01),72 h后逐渐恢复并相对稳定在一定水平。结论挤压伤后由于缺血再灌注等多种因素可导致心肌正性变力及变时效应减低,以致心肌纤维收缩性能及节段旋转功能明显降低,伤后12～24 h为心肌受损达峰时间段。Objective To evaluate the cardiac segmental rotation function of rabbits during the paradoxical expansion after crush injury by speckle tracking echocardiography（STE） ,and to assess myocardial secondary damages after the crush injury. Methods Forty - two New Zealand rabbits were made into animal models of crush injury and were randomly divided into seven groups, i. e. control group, immediate decompression group and groups in 6,12,24,48 and 72 h after the decompression（in each group n = 6）. The segmental rotation function during left ventricle contraction was detected at different times before the crush and after the decompression. Results The segmental rotation function during the contraction in the region of interest （ROI） decreased to the lowest 12 - 24 h after the decompression（P 〈 0.01 ）, and it gradually recovered and became stable at a certain level 72 h after the decompression. Conclusion After the crush injury, various factors such as ischemia and reperfusian may cause positive inotropism in myocardium and the decrease of chronotropic effects,which results in the obvious decrease of myocardial contractility and segmental rotation function. The myocardial damage reaches to the peak in 12 - 24 h after the crush iniurv.

关 键 词：挤压伤 心肌 超声心动图 斑点追踪 旋转 

分 类 号：R541[医药卫生—心血管疾病]