TGF-β1+869T/C基因多态性与儿童哮喘相关性的探讨  

PRIMARY STUDY ON THE CORRELATION BETWEEN TGF-Β1+869T/C POLYMORPHISM AND CHILDREN ASTHMA

作　　者：冯雪梅 董金涛 冯锦辉 陈盛强[3] 

机构地区：[1]广州市番禺区石碁人民医院,广东广州511450 [2]广州市白云区第一人民医院,广东广州510510 [3]广州医学院第二附属医院,广东广州510260

出　　处：《现代医院》2012年第6期73-75,共3页Modern Hospitals

基　　金：番禺区科技项目(编号:2011-z-03-19)

摘　　要：目的探讨转化生长因子TGF-β1+869T/C基因多态性与儿童哮喘的关系。方法运用多聚酶链反应技术检测100例儿童哮喘及100例正常儿童转化生长因子TGF-β1+869T/C基因多态性。结果儿童哮喘组转化生长因子TGF-β1+869 C/C、T/C、T/T表型频率分别为:0.230 0、0.480 0、0.290 0,对照组分别为0.220 0、0.470 0、0.310 0;儿童哮喘组TGF-β1+869C、TGF-β1+869 T基因频率分别为:0.470 0、0.530 0,对照组分别为:0.455 0、0.545 0;TGF-β1+869T/C各种基因型频率在儿童哮喘组与正常对照组之间差异无统计学意义(p>0.05)。结论 TGF-β1+869T/C基因多态性与儿童哮喘无明显相关。Objective To investigate the relationship between TGF 131 ＋ 869T/C polymorphism and chil dren asthma. Methods The polymorphism of TGF 131 ＋ 869T/C gene was screened by PCR RELP in 100 chil dren with asthma and 100 normal children. Results The gene frequency of TGF β1 ＋ 869T/C in asthma group was as follow, TGF 131 ＋ 869 C/C ,T/C ,T/T genotype frequency ：0. 230 0,0. 480 0,0. 290 0, TGF βl ＋ 869 C ,TGF [M ＋869 T Gene frequency： 0. 470 0,0. 530 0. TGF 131 ＋ 869 C/C,T/C,T/T genotype frequency in control group was as follow, 0. 220 0,0.470 0,0. 310 0; and TGF β1 ＋ 869C, TGF β1 ＋ 869 T Gene frequency： 0. 455 0,0. 545 0, There were no significant differences in the frequencies of TGF β1 ＋ 869T/C gene between Asthma patients and control group（p 〉0.05 ）. Conclusion No evident association was found between TGF β1 ＋ 869T/C oolvmorohism and asthma.

关 键 词：哮喘 转化生长因子TGF-β1+869T/C 多态性 

分 类 号：R683[医药卫生—骨科学]