超声射频信号技术分析妊娠高血压综合征孕妇颈动脉血管功能的研究  

Evaluation of carotid arterial intima-media thickness and elasticity in pregnancy-induced hypertension using ultrasound radio-frequency technique

作　　者：薛丹[1] 袁丽君[1] 段云友[1] 杨一林[1] 曹铁生[1] 

机构地区：[1]第四军医大学唐都医院超声诊断科,西安710038

出　　处：《中华医学超声杂志（电子版）》2012年第6期13-15,共3页Chinese Journal of Medical Ultrasound(Electronic Edition)

基　　金：陕西省科技计划项目基金(编号2011K15-02-05)

摘　　要：目的采用超声射频信号血管分析技术对妊娠高血压综合征(PIH)孕妇颈动脉内中膜厚度及弹性进行综合评估,并与正常妊娠孕妇比较,观察PIH孕妇颈动脉血管功能的变化。方法PIH孕妇27例(PIH组),平均动脉压108 mm Hg(1 mm Hg=0.133 kPa),采用年龄及孕周匹配的30名正常妊娠孕妇作为健康对照组。彩色多普勒超声诊断仪分别启用超声射频信号技术中的血管内-中膜定量技术(QIMT)及血管硬度定量分析技术(QAS)测量两组孕妇颈动脉内-中膜厚度IMT及弹性。结果 PIH组孕妇颈总动脉IMT、脉搏波传播速度(PWV)、等容收缩期到射血期转折点压力(PT1)、动脉增强压(AP)及动脉压增强指数(AIx)分别为(466.84±118.50)μm、(7.09±1.97)m/s、(127.50±14.29)mm Hg、(5.14±3.39)mm Hg及(7.58±8.73)%,健康对照组分别为(386.58±125.79)μm、(5.95±1.11)m/s、(105.89±11.02)mm Hg、(1.98±2.19)mm Hg及(-4.79±7.92)%。两组比较差异有统计学意义(t值分别为2.660、2.660、3.460、3.460、3.460,P值均<0.01)。结论与正常妊娠孕妇比较,PIH孕妇颈动脉内中膜明显增厚,弹性减低。超声射频信号血管分析技术可敏感地反映弹性血管结构和功能变化。Objective To evaluate carotid intima-media thickness（IMT） and elasticity in patients with pregnancy-induced hypertension（PIH） using ultrasound radio-frequency data（RF-data） technology.Methods Twenty-seven PIH women（mean brachial blood pressure：108 mm Hg,1 mm Hg=0.133 kPa）were included and thirty age- and gestational week-matched normal pregnant women served as controls.Carotid IMT and stiffness were evaluated using quality IMT（QIMT） and quantitative artery stiffness（QAS）techniques with color Doppler.Results Carotid IMT and elasticity parameters,including pulse wave velocity,pressure at T1,arterial augmented pressure（AP） and arterial augmented pressure index（AIx） were significantly higher in PIH group than in the normal group[IMT：（466.84±118.50）μm vs （386.58±125.79）μm;PWV：（7.09±1.97）m/s vs （5.95±1.11） m/s;PT1：（127.50±14.29） mm Hg vs （105.89±11.02）mm Hg;AP：（5.14±3.39） mm Hg vs （1.98±2.19）mm Hg;AIx：（7.58±8.73）% vs （-4.79±7.92）%）], and there were significant differences（t=2.660,2.660,3.460,3.460,3.460,all P〈0.01）.Conclusions PIH women have significantly increased carotid IMT and decreased elasticity compared with normal pregnant women.Radio-frequency technique could reliably reflect the changes of the carotid arterial structure and elasticity in patients with pregnancy-induced hypertension.

关 键 词：超声检查 多普勒 彩色 高血压 妊娠性 颈动脉 动脉弹性 内中膜厚度 

分 类 号：R714.246[医药卫生—妇产科学]