原因不明复发性流产患者流产与妊娠状态外周血NK细胞数量变化研究  

Study and clinical significance of the alteration of NK cells from human peripheral blood of the patients with unexplained recurrent spontaneous abortion(URSA) in pregnancy

作　　者：许玲[1] 朱凌云[1] 邓立峰[1] 茅挺[1] 张弘[1] 

机构地区：[1]苏州大学附属第二医院,215004

出　　处：《中国现代医药杂志》2012年第5期15-17,共3页Modern Medicine Journal of China

摘　　要：目的探讨原因不明复发性流产(URSA)患者流产与妊娠状态外周血NK细胞数量变化及其临床意义。方法回顾性分析2008～2011年于我院诊疗的URSA流产组39例、URSA妊娠组22例作为研究组,正常早孕组31例、正常非孕组25例作为对照组。使用流式细胞术检测外周血自然杀伤细胞(NK)的含量。结果①URSA流产组(清宫前)与URSA妊娠组、正常早孕组患者比较,前者NK细胞比例明显升高,差异有统计学意义(P<0.05)。②与正常非孕组妇女比较,URSA流产后1、2、3、4、5、6月组患者NK细胞比例均明显升高,差异有统计学意义(P<0.05)。结论原因不明复发性流产发生与NK细胞对胚胎的杀伤增强有关,外周血NK细胞>12%可作为监测URSA患者的指标。Objective To investigate the alteration of NK cells from human peripheral blood of the patients with unexplained recurrent spontaneous abortion（URSA） in pregnancy. Methods Analyzed the clinical data of URSA patients in our hospital from 2008 to 2011.All patients were divided into 4 groups. URSA inevitable abortion group including 39 cases inevitable abortion in early pregnancy,URSA pregnancy group including 22 cases,31 cases of normal early pregnancy group and 25 cases of normal nonpregnant group. Fluorescence flow cytometry was used to measure the frequency of immunocytes from human peripheral blood of NK cells. Results Comparing of URSA pregnancy group and normal early pregnancy group,the NK cells was also increased and presented statistical significance （P〈0.05）.When compared with the normal nonpregnant group, the ratio of NK cells were significantly increased after aborted at lth,2nd,3rd,4th,5th,6th month （P〈0.05）. Conclusion The occurrence of URSA might be associated with enhancement of cellular immune kiUing function mediated by NK ceils. The percentage of NK ceils （12%）from human peripheral blood can be used as an acute index in monitoring URSA patients.

关 键 词：复发性流产 妊娠 自然杀伤细胞 

分 类 号：R714.21[医药卫生—妇产科学]