非洲135例疟疾回顾性分析  

Retrospective Analysis on 135 Cases of Malaria in Africa

作　　者：陈晓红[1] 赵志刚[1] 王慧媛[1] 

机构地区：[1]首都医科大学附属北京天坛医院药剂科,北京100050

出　　处：《中国药物警戒》2012年第6期327-329,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的了解非洲疟疾的临床特点、诊治方法及其转归。方法分析135例疟疾患者的临床资料。结果临床表现中,发热135例(占100%),其中以贫血31例(占22.96%),脾肿大27例(占20.00%),腹泻21例(占15.56%),呕吐19例(占14.07%)最为常见;其次是咳嗽17例(占12.59%),寒战7例(占5.19%)等多种症状。135例均接受青蒿素类抗疟药的综合治疗,治愈135例,无死亡病例。结论非洲疟疾大多数是恶性疟,且发病率很高,临床表现复杂多样且不够典型;尽早诊断、及时治疗是改善本病预后的关键;青蒿素类药物是治疗疟疾安全、有效的首选药物。Objective To understand the clinical characteristics, treatment and its outcome of African malaria. Methods Clinical data of 135 malaria patients are analyzed. Results Among the clinical manifestations, 135 cases（accounting for 100%） got fever, in which there are 31 patients with anemia（accounting for 22.96%）, 27 patients with splenomegaly （accounting for 20.00%）, 21 patients with diarrhea（accounting for 15.56%）, and 19 patients with vomiting（accounting for 14.07%）. All above are the most common clinical manifestations. Then there are various symptoms as cough（17 patients, accounting for 12.59%）, chill（7 patients, accounting for 5.19%） and so on. 135 patients all accepted antimalarial treatment with artesunate drugs. These 135 patients were cured and no one died. Conclusion Most African malaria is malignant with a high morbility, and clinical manifestations are complicated and not typical. So early diagnosis and prompt treatment are the key to improve the disease prognosis. Artesunate drugs are safe, effective and the first choice to malaria treatment.

关 键 词：疟疾 治疗 青蒿素类药物 恶性疟疾 

分 类 号：R969.3[医药卫生—药理学]