不同电针强度与药物剂量刺激效应量的相对关系——针药效应差异性的实验研究  

Relative Relationship of Stimulative Effects on Rat Brachycardia between Different Stimulus Intensities of Electro-acupuncture and Drug Dose Intensity

作　　者：王文升[1] 金宏柱[1] 王耀帅[1,2] 徐斌[1] 方剑乔[2] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]浙江中医药大学,浙江杭州310053

出　　处：《针灸临床杂志》2012年第5期61-65,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：浙江省"重中之重"学科(针灸推拿学)开放基金;项目编号:ZTK2010B09;江苏省普通高校研究生科研创新计划项目

摘　　要：目的:观察不同剂量的普萘洛尔(心得安)维持给药量和不同强度的电针刺激郄门穴对心动过缓模型大鼠心功能的影响,研究不同的药物剂量和不同的电针强度间的效应差异。方法:用普萘洛尔建立心动过缓的大鼠模型,观察不同剂量的普萘洛尔维持给药量(低量、中量、高量)、不同强度的电针刺激(2 mA、4 mA、6 mA)对大鼠心率(HR)、平均动脉压(MAP)、左心室收缩压(LVSP)的影响效应的差异。结果:以心率(HR)、平均动脉压(MAP)、左心室收缩压(LVSP)为观察指标,不同剂量(低量、中量、高量)的维持给药量的效应差异有显著性意义(P<0.05);不同强度的电针刺激郄门穴均有改善心率、左心室收缩压的作用(P<0.01),其效应大小趋势是6 mA>4 mA>2 mA,而对平均动脉压的影响无显著性差异(P>0.05);2 mA和4 mA组,2 mA和6 mA组之间对心率、左心室收缩压影响的差异均有显著性意义(P<0.05),4 mA组和6 mA组之间对心率、左心室收缩压影响的差异无显著性意义(P>0.05)。不同强度的电针对平均动脉压的影响相互之间差异均无显著性意义(P>0.05)。电针4 mA高量对照组与电针4 mA组及电针2 mA组之间的效应差异均有极显著性意义(P<0.01),电针4 mA低量对照组与电针4 mA组及电针6 mA组之间的效应差异均无显著性意义(P>0.05)。结论:不同剂量的心得安维持给药量和不同强度的电针刺激郄门穴对心动过缓模型大鼠心功能影响的量效关系不同,针药结合组之间的差异无统计学意义,在一定程度上提示了某一针灸刺激量与药物刺激量的效应相当以及用药物评价针灸效应的可能性。Objective：To observe the difference of regulatve effect on rat brachycardia between different maintain doses of propranolol（Inderal） and different stimulus intensities of electro-acupuncture（EA）at Ximen point,to study the differences of the effects between different doses of drug and different stimulus intensities of EA.Methods：Brachycardia was induced by propranolol in SD/Wistar rats.Using different maintaining dosage of propranolol（low dosage,middle dosage,high dosage） and different stimulus intensity（2 mA,4 mA,6 mA） of EA to investigate the different regulative effects on heart rate（HR）,mean arterial pressure（MAP）,left ventricular systolic pressure（LVSP）.Results：The HR,MAP,LVSP were observed.There were significant differences of HR,MAP and LVSP between different dosages（P4 mA〉2 mA,and there was no significant difference on the impact of MAP（P〉0.05）;HR and LVSP of group 4 mA and 6 mA were significantly different when compared with 2 mA（P0.05）.Different stimulus intensities of EA had no significant difference on MAP（P〉0.05）.There was a significant difference of effect of group 4 mA combind with high-dosage when compared with 4 mA and 2 mA（P0.05）.Conclusion：The dose-effect relationships are different between different maintain doses of propranolol and different stimulus intensities of EA at Ximen point in bradycardia rats,and there is no significant difference between acupuncture combined with drug groups extent an acupuncture effect and drug effect and the possibility to evaluate the effects of acupuncture with drugs.

关 键 词：电针强度 心动过缓 大鼠 针药效应 

分 类 号：R245.97[医药卫生—针灸推拿学]