耐力训练对大鼠FTO基因表达影响及与摄食量关系研究  

The Relationship between FTO Gene Expression and Food Intake by Endurance Training in Rats

作　　者：马国栋[1] 铁钰[2] 刘艳环[1] 王秋灵[1] 赵宁[1] 

机构地区：[1]山东理工大学体育学院,山东淄博255049 [2]辽宁师范大学体育学院,辽宁大连116029

出　　处：《体育科学》2012年第6期69-73,共5页China Sport Science

基　　金：山东理工大学青年教师发展支持计划(110026)

摘　　要：目的:研究耐力训练对大鼠FTO基因表达的影响以及与摄食量的关系。方法:以SD大鼠为研究对象,将大鼠分为对照组(C组)和运动训练组(E组),以12周无负重游泳为运动手段,测定肝脏、骨骼肌、脂肪组织和下丘脑组织中FTO基因mRNA表达、大鼠体重、肾周与附睾周围脂肪重量及脂肪重量与体重百分比、大鼠每天摄食量。结果:FTO基因mRAN在骨骼肌、脂肪组织和下丘脑中表达均显著高于肝脏组织,下丘脑显著高于骨骼肌和脂肪组织,脂肪组织与骨骼肌未见显著性差异,耐力训练对肝脏、骨骼肌和脂肪组织中FTO基因mRNA表达未见显著性影响,而脑组织表达显著升高;大鼠体重在不同的对应时间点,运动训练组与对照组未见显著性差异;大鼠摄食量在不同对应时间点,运动训练组显著高于对照组;肾周及附睾周围脂肪组织重量及脂肪重与体重百分比运动训练组显著低于对照组。结论:耐力训练可以提高下丘脑中FTO基因表达,从而刺激大鼠提高摄食量,而运动能量的消耗抵消了因摄食增加引起的体重增加。Objective： To investigate the relationship between FTO gene expression and intake food by endurance training in rats. Methods：The rats were randomly divided into control and endurance trained group. This paper analyzed the mRNA expression of FTO in liver and skeletal muscle, adipose tissue and hypothalamus, body weight, adipose tissue weight around kidney and epididymis, average food intake per day in rats after 12 week unload swimming training. Results ： The Fro gene mRNA expressions in skeletal muscle, adipose tissue and hypothalamus were higher than in liver, its expression in hypothalamus was higher than in skeletal muscle and adipose tissue, but its expression in skeletal muscle and adipose tissue was no significant dif- ferent. Endurance training up-regulated FTO gene expression in hypothalamus, however, there was no change in skeletal muscle,liver and adipose tissue. The rat weight was no significant different in parallel time point, but food intake significantly increased in trained rats. Adipose tissue weight around kidney and epididymis decreased significantly in trained rats. Conclusion： Endurance training increased the FTO gene expression in hypothalamus which stimulated more food intake. However, the rat weight was no change for exercise expending more energy.

关 键 词：耐力训练 脂肪质量与肥胖相关基因 大鼠 摄食量 

分 类 号：G804.7[文化科学—运动人体科学]