自身免疫性甲状腺疾病患者唾液腺功能研究  

Salivary gland function in patients with autoimmune thyroid disease

作　　者：张丽霞[1] 陈金燕[1] 亓丽丽[1] 任妍[1] 苏君梅[2] 

机构地区：[1]浙江省中医院核医学科,杭州310006 [2]杭州师范大学基础医学部病理生理教研室

出　　处：《浙江医学》2012年第10期766-768,I0002,共4页Zhejiang Medical Journal

摘　　要：目的 通过在自身免疫性甲状腺疾病患者甲状腺显像过程中加入唾液腺显像,旨在探讨自身免疫性甲状腺疾病患者唾液腺功能的改变,以便指导临床在治疗此类疾病过程中同时关注患者唾液腺功能.方法 选取35 例Graves 病患者,15 例桥本甲状腺炎和同期同年龄唾液腺功能正常者35例.Graves 病及桥本甲状腺炎患者在甲状腺显像同时进行唾液腺显像.在甲状腺显像注射显像剂后常规等待的30min 行唾液腺动态显像,通过勾画ROI,获得双侧腮腺、颌下腺时间- 放射性曲线,并通过计算可进一步获得各腺体泌锝率（Ex%）及泌锝时间（Tex）等定量指标.结果 Graves 病组主要唾液腺泌锝功能均明显降低;桥本甲状腺炎组主要唾液腺泌锝功能亦明显降低;所有患者泌锝时间无明显延长;Graves病患者甲状腺30min 摄锝率与主要唾液腺功能降低程度无明显相关性（均P ＞0.05）.结论 在行常规甲状腺显像过程中加做唾液腺功能显像,通过一次静脉注射显像剂,不仅获得了甲状腺功能指标而且获得了唾液腺功能指标,操作简单,时间安排合理,值得常规使用,以便指导临床早期发现疾病并进行有效治疗.Objective To investigate the salivary gland function changes in patients with autoimmune thyroid disease. Methods Thirty five patients with Graves＇ disease （7 males and 28 females,aged 49.62 ± 11.10y）, 15 patients with Hashimoto thyroiditis （5 males and 10 females, aged 45.67 ± 9.85 y）and 35 age- and sex-matched healthy subjects were included in the study. All subjects underwent routine thyroid scintigraphy imaging and sativery gland dynamic imaging. Time - activity curve of bilateral parotids and bilateral submandibulars were obtained by outlining regions of interest （ROI） of these glands,excreting technetium rate （ex%） and excreting technetium time （Tex） of each gland were calculated. Results The excreting technetium function of major salivary glands decreased significantly in Graves＇ disease patients（P〈0.05 ）. The excreting technetium function in major salivary glands of Hashimoto thyroiditis decreased significantly（P〈0,05 ）. The time of excreting technetium of major sali- vary gland was not longer than that of normal controls. The major salivary gland function was not correlated with thyroid tech- netium uptake rate at 30 min in G raves＇ disease patients （ r= -0.1768,-0.2753, -0.2596, -0.1747; P= 0.3331,0.1299,0.1514,0.3388 ）. Conclusion With salivary gland dynamic imaging during routine thyroid scintigraphy, thyroid function parameters and salivary gland function indicators can be obtained simultaneously.

关 键 词：自身免疫性 疾病放射性核素显像 GRAVES病 甲状腺炎 唾液腺 

分 类 号：R581[医药卫生—内分泌]