HCV特异性T淋巴细胞输注疗法治疗慢性丙型肝炎的临床研究  

Clinical study on the adminstration of human specific CTL for HCV to chronic hepatitis C

作　　者：史继静 崔中锋 李广明 

机构地区：[1]河南省传染病医院,河南郑州450000

出　　处：《中国医药导报》2012年第17期90-91,共2页China Medical Herald

摘　　要：目的探讨HCV特异性T淋巴细胞疗法的抗病毒疗效。方法应用此疗法治疗慢性丙型肝炎30例,观察治疗后肝功能、HCV RNA、抗-HCV等的变化,并追踪随访半年。结果经该疗法治疗后患者肝功能明显改善,HCVRNA阴转率达56.67%,且进一步研究发现治疗前患者体内HCV RNA≤105copies/mL时病毒阴转率显著高于HCVRNA>105copies/mL时(72.22%vs 33.33%)。结论 HCV特异性T淋巴细胞输注治疗慢性丙型肝炎是安全有效的。Objective To study the effect of the therapy of specific CTL for HCV on hepatitis C.Methods 30 patients with chronic hepatitis C were administrated to the therapy of specific CTL for HCV and followed up for six months.Liver function test,HCV RNA,anti-HCV were detected.Results The liver function of patients were improved significantly and 17 of 30（56.67%） patients were HCV RNA negative after therapy.Further more,the ratio of HCV-RNA changing negative was higher in patients with HCV RNA ≤105 copies/mL than in patients with HCV RNA 105 copies/mL（72.22% vs 33.33%）.Conclusion The therapy of specific CTL for HCV on hepatitis C is safe and effective for treating chronic hepatitis C.

关 键 词：慢性丙型肝炎 细胞毒性T淋巴细胞 丙型肝炎病毒 

分 类 号：R512.63[医药卫生—内科学]