长疗程使用万古霉素肾毒性2例观察  

Two cases observation of nephrotoxicity on long-term treatment with Vancomycin

作　　者：俞志勇[1] 李欲航[1] 李渤涛[1] 胡亮钉[1] 陈虎[1] 

机构地区：[1]军事医学科学院附属医院造血干细胞移植中心,北京100071

出　　处：《中国医药导报》2012年第17期129-131,共3页China Medical Herald

摘　　要：万古霉素是治疗G+球菌感染最重要的抗生素,但其肾毒性副作用也是危险的。本文观察2例急性髓性白血病患者,化疗后出现严重软组织感染,给予长疗程静脉使用万古霉素抗感染治疗,同时严密监控肾毒性发生情况。经过上述治疗,2例患者严重感染均得到有效控制直至痊愈,整个用药过程中2名患者均未出现明显的肾功能损伤情况。说明对于大多数患者而言,使用万古霉素进行抗感染治疗是有效的,而且肾毒性的发生率较低,不会因此而影响患者的主要治疗。Vancomycin is the most important antibiotics towards G＋ coccus,but the side effect of renal toxicity is danger too.This article reports two acute myeloid leukemia patients with severe soft tissue infection after chemotherapy treated with long-term intravenous infusion of vancomycin while closely monitoring the occurrence of renal toxicity.After the above treatment,two patients with severe infections had been effectively controlled until healed.Two patients showed no obvious renal function damage during the treatment.The outcome suggest that for the majority of patients,vancomycin is obvious and effective in anti-infection treatment.The incidence of nephrotoxicity is very low,so it should not affect the primary treatment of patients.

关 键 词：万古霉素 长疗程治疗 肾毒性 

分 类 号：R978.1[医药卫生—药品]