中药木回春对肿瘤细胞株的杀伤作用  

The cell killing effects of traditional Chinese medicine Mu Hui Chun on liver and lung tumor cell

作　　者：杨世忠[1] 刘铁军[1] 杨玉洁[1] 白静丽[1] 张静敏[2] 

机构地区：[1]长春中医学院附属医院,长春130021 [2]白求恩医科大学药学院生药教研室

出　　处：《中国老年学杂志》2000年第2期99-100,共2页Chinese Journal of Gerontology

基　　金：吉林省科委八五攻关课题

摘　　要：目的　观察中药木回春体外抗肝癌、肺癌的作用。方法　采用 3H- Td R掺入法检测木回春对人肝癌细胞 QGY- 770 3和人肺癌细胞 SPC- A- 1细胞的抑瘤效应。结果　对人肝癌细胞半数生长抑制值为 462 .1μg/ ml,对 QGY- 770 3细胞 DNA合成量较对照组皆有明显减少 ,差异显著 (P<0 .0 0 1 ) ,其合成量随药物浓度增加呈减少趋势。 ED5 0 值为 2 70 .9μg/ ml;对 SPC- A- 1细胞半数生长抑制值为51 2 .7μg/ ml。结论　木回春很可能成为治疗多种肿瘤的理想药物。To observe the anti liver and lung tumors responses of Mu Hui Chun in vitro.Methods Using 3 H thymidine deoxyribose( 3 H TdR) incorporation technique to detect the inhibitive effect of Mu Hui Chun on the DNA synthesis of liver tumor QGy 7703 cell and lung tumor SPC A 1 cell respectively.Results Median cell growth inhibitive dose of QGy 7703 cell was 462 1 μg/ml,the amount of QGy 7703 cell DNA sythesis was siginificantly less than that in the control group,with the higher concentration of Mu Hui Chun accompanied by the lower amount of DNA synthesis,and the value of ED 50 was 270,968 μg/ml.As to SPC A 1 cell,the median cell growth inhibitive dose was 512 7 μg/ml.Conclusion Mu Hui Chun has potential anti turmor property.

关 键 词：木回春 肿瘤细胞株 ^3H-TDR 中医药疗法 

分 类 号：R286.91[医药卫生—中药学]