骨痹镇痛巴布膏镇痛及对免疫性关节炎试验研究  

Analgesic and anti-Autoimmune Arthritis Effect of Gubi analgesic Cataplasms

作　　者：孙明江[1] 杨光[1] 肖艳芳 谭颖[1] 吕旭潇[1] 孙超[1] 

机构地区：[1]山东中医药大学,250355 [2]潍坊市立医院

出　　处：《世界中医药》2012年第3期258-260,共3页World Chinese Medicine

摘　　要：目的:研究骨痹镇痛巴布膏镇痛及对免疫性关节炎的影响。方法:以骨痹镇痛巴布膏大、中、小三个剂量及阳性对照药麝香壮骨膏和基质对照组给药,分别以小鼠、大鼠为实验对象对主要药效学指标进行了试验研究。结果:骨痹镇痛巴布膏能够提高热板法及醋酸所致小鼠扭体法小鼠的痛阈值、减少扭体次数;对免疫性关节炎有明显的预防和治疗作用,明显减小免疫性关节炎的足体积,降低关节炎的严重程度。结论:骨痹镇痛巴布膏具有明显的镇痛和对抗免疫性关节炎的作用。Objective ： To investigate analgesic and anti- autoimmune arthritis effect of Gubi analgesic Cataplasms. Methods： The experi- ment was carried out on five groups： the low-dose group, the middle-dose group, the high-dose group, the Shexiang Zhuanggu Gao group, and the matrix control group. The main pharmacodynamic index was investigated by using rats and mice respectively for the test targets. Results： Gubi analgesic Cataplasms increased the pain threshold value of mice by hot-plate procedures, decreased twist times of mice, which was favorable indices for prevention and treatment of autoimmnne arthritis, and significantly reduced foot size of immune ar- thritis, decrease the severity of arthritis. Conclusion：Gubi analgesic Cataplasms have confirmed analgesia and anti-autoimmune arthritis effect.

关 键 词：骨痹镇痛巴布膏 镇痛 免疫性关节炎 

分 类 号：R285.5[医药卫生—中药学]