干扰素α_(2b)和病毒唑联合治疗慢性丙型肝炎的疗效观察  

The Effect of Interferon α_(2b) and Ribovirin Combination Therapy in Patients with Chronic Hepatitis C

作　　者：闵贤 黄祖瑚 许家璋[2] 黄远成[3] 钱兴南 殷杰 吴文漪[6] 贺玲莉 杨冬明 赵耘 唐保元 

机构地区：[1]南京医科大学第一附属医院传染病科,南京210029 [2]中国人民解放军八一医院,南京210002 [3]南京市鼓楼医院,南京210008 [4]无锡市传染病院,无锡214000 [5]南京化学工业公司医院,南京210044 [6]徐州医学院附属医院,徐州221000 [7]徐州市第五人民医院,徐州221000 [8]扬州市苏北人民医院,扬州225000 [9]扬州市第三人民医院,扬州225000

出　　处：《南京医科大学学报（自然科学版）》2000年第2期104-106,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的　观察干扰素α2 b和病毒唑联合疗法与单用干扰素α2 b治疗慢性丙型肝炎的生化、病毒学应答以及使用安全性评估。方法　慢性丙型肝炎患者 5 0例 ,随机双盲分为干扰素α2 b(3MU,每周 3次 )和病毒唑 (1 0 5 0 m g/ d)联合治疗组与单用干扰素α2 b治疗组。疗程 2 4周 ,停药后再随访 2 4周 ,在治疗 2 4周、随访 2 4周时不能测得 HCV RNA为病毒学立即和持续应答。结果　治疗结束时联合治疗组 2 3例 (76 .6 7% )达到病毒学应答 ,而对照组仅 9例 (45 .0 0 % ,P<0 .0 5 )。在随访期联合治疗组病毒学持续应答率也较对照组高 (P<0 .0 5 )。联合疗法也可用于以往曾单用干扰素无效的病人 ,并取得较好的疗效。结论　干扰素α2 b和病毒唑联合治疗慢性丙型肝炎较单用干扰素α2 b具有较高的病毒学应答。Objective To investigate the biochemical and virological response and safety of treatment with interferon α 2b and ribavirin compared with interferon α 2b alone. Methods In this double blind trial 50 patients were randomly assigned to treatment with interferon α 2b (3 MU three times a week) in combination with ribavirin (1 050 mg per day) or interferon α 2b alone for 24 weeks and then followed for a further 24 weeks. The primary endpoint was the sustained virological response defined as no detectable HCV RNA by PCR at both week 24 and week 48. Results Twenty three (76.67%) of the 30 patients in the interferon α 2b and ribavirin group had a virological response compared with nine (45.00%) of the 20 patients in the interferon α 2b alone group (\%P\%<0.05). At the follow up, the proportion of patients with a virological response was greater in the interferon α 2b and ribavirin group than the interferon α 2b alone group (\%P\%<0.05). Combined therapy may be better for chronic hepatitis C in patients with a previous non response to interferon alone. Conclusion Most of the patients with chronic hepatitis C have a sustained virological response with combine interferon α 2b and ribavirin therapy. The combine therapy is better than the only interferon α 2b treatment.

关 键 词：慢性 丙型肝炎 干扰素 病毒唑 药物疗法 

分 类 号：R512.630.5[医药卫生—内科学] R978.7[医药卫生—临床医学]