冠状动脉慢血流患者血清炎性标志物的检测水平及意义  

Markers of inflammation in patients with coronary slow-flow

作　　者：何疆春[1] 杨晔[1] 张宁坤[1] 李田昌[1] 朱智明[1] 刘敏[2] 王兆君[1] 刘英明[1] 

机构地区：[1]海军总医院心脏中心,北京100048 [2]海军总医院检验科,北京100048

出　　处：《心肺血管病杂志》2012年第3期246-248,共3页Journal of Cardiovascular and Pulmonary Diseases

基　　金：海军总医院2009年创新基金资助项目(编号CX200908)

摘　　要：目的:探讨重要炎症因子高敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)及肿瘤坏死因子-α(TNF-α)在冠状动脉慢血流(CSF)发生发展中的作用及临床意义。方法:选择经冠状动脉造影(CAG)检查诊断为CSF患者20例,CAG显示无管腔狭窄及无慢血流的正常血流速度(NCF)者24例为对照组,使用校正的TIMI血流分级(CTFC)方法评价冠状动脉血流速度,并分别测定2组的血清高敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)及肿瘤坏死因子-α(TNF-α)。结果:2组在年龄、性别、高血压史、早发冠心病家族史、吸烟及血脂等方面均无明显差别。CSF组血清MMP-9、TNF-α水平较NCF组明显增高(P<0.05),但2组的hs-CRP、IL-6水平差异无统计学意义。结论:血清MMP-9、TNF-α2种炎症因子可能介导或参与了CSF形成的发生、发展过程,对血清MMP-9、TNF-α水平的检测及对CSF的诊断有一定的判断作用,值得临床进一步地探讨。Objective：To evaluate the significance of using serum high sensitivity C-reactive protein（hs-CRP）,interleukin-6（IL-6）,matrix metallo proteinase（MMP）-9,tumor necrosis factor-a（TNF-α）,as markers in the diagnosis of Coronary slow-flow（CSF）.Methods：Twenty patients with CSF and 20 control cases with normal coronary flow（NCF） pattern were enrolled in the study.Coronary flow patterns of the cases were determined by Thrombolysis in Myocardial Infarction（TIMI） frame count method.The change of serum hs-CRP,IL-6,MMP-9,TNF-α were measured.Results：There was no difference between two groups with respect to age,gender,history of smoking,hypertension,a family history of premature cardiovascular disease,triglyceride,total cholesterol,high density lipoprotein,low density lipoprotein,apoprotein apolipoprotein A1 and apolipoprotein B levels.The levels of serum MMP-9、TNF-α in the CSF group were obviously higher than the NCF group（P〈0.05）,but the levels of hs-CRP and IL-6 showed no significant difference.Conclusion：MMP-9 and TNF-α maybe involved in the pathogenesis of coronary slow-flow.

关 键 词：冠状动脉疾病 慢血流 基质金属蛋白酶-9 肿瘤坏死因子-α 高敏C反应蛋白 

分 类 号：R541[医药卫生—心血管疾病]