静脉输注高氧液和高渗盐水对创伤性失血性休克兔动脉血气的影响  

Effect of hyperoxia solution and hypertonic saline infusion on the arteries blood gas analysis of rabbits with traumatic hemorrhagic shock

作　　者：胡怀宁[1] 王大军[1] 刘莹莹[2] 许铁[3] 

机构地区：[1]徐州医学院研究生院,221000 [2]徐州市第三人民医院护理部,221000 [3]徐州医学院附属医院急救中心,221000

出　　处：《中华现代护理杂志》2012年第14期1630-1632,共3页Chinese Journal of Modern Nursing

摘　　要：目的探讨静脉输注高氧液和高渗盐水对创伤性失血性休克兔动脉血气的影响，及两者的交互作用。方法采用Lamson’s法建立创伤性失血性休克兔模型。按照高氧液和高渗盐水两因素的有无，采用2×2析因设计，将40只日本长耳大白兔分为4组（n=10）：生理盐水组（NS组）、生理盐水高氧液组（NSO组）、高渗盐水组（HS组）、高渗高氧液组（HSO组）。于休克前即基础期（T1）、休克末（12）、限制复苏期末（T3）、止血复苏期末（T4）各时间点采取动脉血进行血气分析。结果各组动物基础和休克末动脉血二氧化碳分压（PaCO2）、动脉血氧分压（PaO2）差异无统计学意义（P〉0．05）。PaCO2在限制复苏期末和止血复苏期末，NSO组（33．50±5．93），（37．22±6．74）mmHg，HS组（31．70±7．39），（35．10±7．56）mmHg，HSO组（38．70±4．92），（41．80±5．51）mmHg和NS组（27．40±3．60），（30．83±2．79）mmHg，4组间比较差异有统计学意义（F值分别为6．894，4．287；P〈0．05），但高氧、高渗两因素间无交互作用（P〉0．05）；PaO2在限制复苏期末和止血复苏期末各组间差异无统计学意义（P〉0．05）。结论高氧液和高渗盐水复苏均能有效缓解过度通气，但两者之间无交互作用。Objective To study the effect of hyperoxia solution and hypertonic saline infusion on arteries blood gas analysis of traumatic hemorrhagic shock rabbits, and interaction of hyperoxia solution and hypertonic saline. Methods Forty rabbits established into traumatic hemorrhagic shock model by Lamson＇ s method. Post hoc analysis was adopted in trial according to hyperoxia solution and hypertonic saline and 40 rabbits were divided into four groups （ n = 10） ： saline （NS） group, normal hyperoxic solution （NSO） group, hypertonic saline（HS） group, hyperosmotic-hyperoxic solution （HSO） group. Then blood samples were collected at pre-shock, post-shock, the end of limited resuscitation and hemostatic resuscitation for blood gas analysis. Results At the pre-shock, post-shock stages, PaCO2 and PaO2 were no significant difference in each groups （ P 〉 0.05 ）. At the end of limited resuscitation and hemostatic resuscitation stage, PaCO2 in NSO group （33.50 ± 5.93） ,（37.22 ±6.74） mm Hg, （31.70 ±7.39）, （35.10 ±7.56 ）mm Hg in HS group,HSO group（38.70 ± 4.92 ）, （41.80 ± 5.51 ） mm Hg were higher than that in NS group （ 27.40 ± 3.60）, （ 30. 83 ± 2.79） mm blg （ F = 6. 894,4. 287, respectively ; P 〈 0.05 ） , but there were no cross correlation between hypertonic saline and hyperoxia solution （ P 〉 0.05 ）. There were no significant difference in PaO2 in each groups at the end of limited resuscitation and hemostatie resuscitation stage （P 〉 0. 05 ）. Conclusions Both hyperoxia solution and hypertonic saline can effectively relieve hyperventilation, but there is no interaction between them.

关 键 词：兔 高氧液 高渗盐水 创伤性失血性休克 血气分析 

分 类 号：R472[医药卫生—护理学]