多波长系数倍率法测定复方甲硝唑含漱液的主药含量  

DETERMINATION OF MAIN INGREDIENTS IN GARGLE METRONIDAZOLE COMPOSITUM BY MULTIWAVELENGTH K ratio SPECTROPHOTOME TRIC METHOD

作　　者：王章阳[1] 王晓敏[2] 郭平[3] 廖工铁[3] 

机构地区：[1]第三军医大学西南医院,重庆400038 [2]华西医科大学口腔医学院 [3]华西医科大学药学院,四川成都610041

出　　处：《华西药学杂志》2000年第1期57-58,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的:建立复方甲硝唑含漱液中甲硝唑及醋酸洗必泰的含量测定方法。方法:用多波长系数倍率法消除各组分间的相互干扰,分光度法则定组分含量。结果:测定波长为260、281、340、312、349nm。甲硝唑、醋酸洗必泰含量测定的平均回收率分别为100.9%,RSD=0.5%和102.0%,RSD=0.69%。结论:本方法简便。OBJECTIVE:To develep a method for determining the contents of Metronidazole(Ⅰ) and Chlorhexidine acetate(Ⅱ) in gargle metronidazole compositum.METHODS:The concentrations of Ⅰ and Ⅱ were deected by mult iwavelength K ratio spectrophotometric method ,influence eath other in spectrum could be removed.RESULTS:Measurement was carried out at 260, 281, 340, 349, 312 nm, the mean recovery were 100.9% ( RSD= 0.%, n=9) for metronidazole and 102.0% ( RSD =0.6%, n=9) for Ⅱ.CONCLUSION:This method was simple,accurate for the measurement of both Ⅰ and Ⅱ.

关 键 词：分光光度法 甲硝唑 醋酸洗必泰 含量测定 

分 类 号：R988.2[医药卫生—药品] R927.2[医药卫生—药学]