聚氰基丙烯酸正丁酯毫微粒中万乃洛韦的含量测定  

DETERMINATION OF VALACICLOVIR IN POLYBUTYLCYANOACRYLATE NANOPARTICLES

作　　者：何勤[1] 张志荣[1] 

机构地区：[1]华西医科大学药学院,四川成都610041

出　　处：《华西药学杂志》2000年第1期60-61,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金!资助课题 (资助号 :3 9470 83 1)

摘　　要：目的:建立测定聚氰基丙烯酸正丁酯毫微粒中万乃洛韦含量的方法。方法:混合溶剂溶解万乃洛韦聚氰基丙烯酸正丁酯毫微粒,用HPLC测定其中的万乃洛韦含量,分析柱为ODS柱,流动相为甲醇-0.02mol·L-1磷酸二氢钾混合液(20∶80),检测波长254nm。结果:测量线性范围2.02～20.20μg·ml-1,回收率为97.30%,RSD为4.90%。OBJECTIVE:To suggest the determination method of valaciclovir in polybutylcyanoac rylate nanoparticle.METHODS: The content of Valaciclovir in polybutylcyanoacrylate nanoparticles was determined by HPLC after dissolving the Valaciclovir polybutylcyanoacrylate nanoparticles in a solvent mixture. The ODS column was used as analytical column, the mobile phase consisted of CH 3OH KH 2PO 4(20∶80).RESULTS:The Linear range was 2.02 20.20 μg·ml -1 , recovery was 97.3%, RSD was 4.90%. CONCLUSION:The method is accurate and can be used as reference for other nanoparticles.

关 键 词：万乃洛韦 高效液相色谱 测定 VACV-PBCA-NP 

分 类 号：R927.2[医药卫生—药学] R979.1