71例结缔组织病患者肺功能临床意义的探讨  

Clinical significance of pulmonary function test among 71 cases of connective tissue disease patients

作　　者：陈莹莹[1] 谭明旗[1] 

机构地区：[1]中国医科大学附属盛京医院第二呼吸内科,110022

出　　处：《辽宁医学杂志》2012年第3期111-113,共3页Medical Journal of Liaoning

摘　　要：目的探讨结缔组织病(CTD)患者肺功能尤其是肺弥散功能的损伤情况及其与病程时间的关系;分析肺功能检测对于CTD肺部疾病的临床意义。方法对我院风湿免疫科已确诊CTD的71例患者进行肺通气功能及弥散功能检测,并与正常组比较。结果 80.00%CTD患者存在肺功能的异常,主要以弥散功能下降为主,其次为肺容积的减少、气道阻塞等。肺功能各项指标的异常率(DLCO)为71.83%,DLCO/肺泡通气量(VA)为31.00%,用力肺活量(FVC)为36.62%,慢肺活量(SVC)为31.00%,1秒用力呼气容积(FEV1)为29.58%,FEV1/FVC为5.60%,VA为69.01%,最大呼气流速(FEFmax)为12.68%,小气道功能(FEF)25%～75%为35.21%。结论 CTD患者肺功能损害主要以肺弥散功能为主,并伴有肺容量的减低等。肺功能检查较肺部CT更早出现异常,对CTD患者肺部疾病的早期发现、治疗及预防有很好的临床意义。Objective To study the pulmonary function in patients with connective tissue disease especially the injury of pulmonary diffusing capacity,and its relationship with the course of disease;Analysis the clinical significance of pulmonary function testing for the pulmonary diseases of CTD.Methods 71 CTD patients who had been confirmed by rheumatic fever immunization branch have been carried out to test the pulmonary ventilation function and diffusing capacity test,and compared with the normal group.Results The injure of pulmonary function in patients.Abnormal rate of lung function indicators are as follows：DLCO is 71.83%,DLCO/VA is 31.00%,FVC is 36.62%,SVC is 31.00%,FEV1 is 29.58%,FEV1/FVC is 5.60%,VA is 69.01%,FEF max is 12.68%,FEF25%~75% is 35.21%.Conclusion The impairment of pulmonary function in patients with CTD mainly dominated by pulmonary diffusing capacity,and accompanied by lung volume reduction.Lung function injury degree and the course was positively correlated.Pulmonary function tests can detect the earlier abnormal phenomenon than CT,and it has an important value for the CTD patients in detecting,treating and preventing the disease earlier.

关 键 词：结缔组织肺病 肺弥散功能 肺间质病变 

分 类 号：R593.2[医药卫生—内科学]