β-内酰胺酶抑制剂——他佐巴坦与舒巴坦酶动力学的比较研究  

Comparative kinetic study of β-lactamase inhibitors tazobactam vs.sulbactum

作　　者：张永龙[1] 李家泰[1] 

机构地区：[1]北京医科大学第一临床医院临床药理研究所,北京100083

出　　处：《中国药学杂志》2000年第4期240-243,共4页Chinese Pharmaceutical Journal

摘　　要：目的 :比较他佐巴坦与舒巴坦的抑酶强弱。方法 :测定Ki 值及IC50 。结果 :他佐巴坦的Ki 值大于舒巴坦的Ki 值 ;他佐巴坦的IC50 小于舒巴坦的IC50 。结论 :他佐巴坦的抑酶作用强于舒巴坦。OBJECTIVE:To compare the inhibitory activity to β lactamase of tazobactam with sulbactum.METHODS:The K i and IC 50 values of tazobactam and sulbactum were measured.RESULTS:The K i value of tazobactam was higher than that of sulbactum and the IC 50 value of tazobactam was lower than that of sulbactum.CONCLUSION:The inhibitory activity of tazobactam was stronger than that of sulbactum.

关 键 词：他佐巴坦 舒巴坦 酶动力学 Β-内酰胺酶抑制剂 

分 类 号：R978.11[医药卫生—药品]