多功能超声评价缬沙坦对高血压病室壁运动的影响  

Effects of Valsartan on Left Ventricular Wall Motion in Patients with Essential Hypertension

作　　者：宋兆琼 康忠俊 梁燕[2] 朱峻[2] 赖小今[2] 

机构地区：[1]资阳市第一人民医院超声科,心内科,四川641300 [2]成都军区总医院超声科,心内科

出　　处：《西南军医》2012年第3期405-408,共4页Journal of Military Surgeon in Southwest China

基　　金：四川省卫生厅科学研究基金资助项目(No.040077)

摘　　要：目的应用新型超声技术自动室壁分区运动分析(ASMA)与全方位M型超声心动图(FAM)技术定量评价血管紧张素Ⅱ受体拮抗剂-缬沙坦对原发性高血压病心脏室壁运动状态的影响。方法原发性高血压病患者178例应用缬沙坦80mg/d口服治疗,疗程12个月。观察患者血压及症状体征的变化情况,并分别在治疗前及治疗后每3个月分阶段应用ASMA-FAM技术观察心脏室壁运动状态的变化情况。结果缬沙坦在治疗二周后血压开始下降,五周后趋于平稳;反映左室壁运动状态的参数指标在治疗3月后开始改善(P<0.05),6个月～1年后改善明显并趋于稳定(P<0.01)。结论缬沙坦不但能够有效改善原发性高血压病所导致的左室重构,而且能够明显改善左室壁运动状态,ASMA-FAM能够全面、客观地定量评价心脏室壁运动状态的情况。Objective To assess quantitatively the effects of valsartan on left ventricular wall motion in patients with essential hypertension by automatic segmental motion analysis （ASMA） and free angle M - mode echocardiography （FAME）. Methods Valsartan was adminis- tered to 178 patients with essential hypertension in a dose of 80mg daily for 12 months. The parameter of their left ventricular wall motion was observed by ASMA and FAME every 3 months Before and after treatment and their blood pressure and symptoms and signs at the same time. Results Blood pressure Began to drop after 2 weeks＇ treatment with valsartan and was tending towards stability 5 weeks later. The pa- rameter of left ventricular wall motion was improved after 3 months＇ treatment（ P 〈0. 05） and evidently 6 months-1year later（P 〈0. 01 ）. Conclusions Valsartan not only improves effectively the left ventricular reconstitution but also the left ventricular wall motion,which can Be evaluated overall and objectively By ASMA and FAME.

关 键 词：自动室壁分区运动分析 全方位M型超声心动图 缬沙坦 高血压病 室壁运动状态 

分 类 号：R540[医药卫生—心血管疾病]