布托啡诺与曲马多复合舒芬太尼用于术后镇痛的比较  

Efficacy and Safety of Comparing Butorphanol with Tramador in Postoperative Analgesia

作　　者：魏江涛[1] 董理[1] 侯明勇[1] 华丽[1] 邓磊[1] 

机构地区：[1]成都大学附属医院,四川成都610081

出　　处：《现代临床医学》2012年第3期188-190,共3页Journal of Modern Clinical Medicine

摘　　要：目的:比较布托啡诺复合舒芬太尼与曲马多复合舒芬太尼用于上腹部手术术后镇痛的安全性及有效性。方法:100例上腹部手术接受全身麻醉患者,随机分为布托啡诺组和曲马多组,每组各50例。布托啡诺组为布托啡诺配伍舒芬太尼,曲马多组为曲马多配伍舒芬太尼。比较2组术后4 h、8 h、16 h、24 h、48 h疼痛视觉模拟评分(visual analogue painscale,VAS)、舒适度评分(Bruggman comfort score,BCS)及Ramsay镇静评分与不良反应。结果:2组术后镇痛效果确切,VAS评分相比无显著性差异(P>0.05);2组舒适度评分(BCS)无显著性差异(P>0.05),布托啡诺组术后Ramsay镇静评分高于曲马多组(P<0.05),头晕发生率布托啡诺组高于曲马多组(P<0.05),恶心呕吐及皮肤瘙痒发生率布托啡诺组低于曲马多组(P<0.05)。结论:布托啡诺与曲马多复合舒芬太尼术后镇痛确切,效果相似;两种配方各有优缺点,可根据病人不同情况选择。Objective： To compare butorphanol combined with sufentanyl to tramadol with sufentanyl in the efficacy and safety after epigastrium operation. Methods ：100 patients who received general anesthesia during selective epigastrium operation, were randomly divided into two groups with 50 cases for each. The butorphanol combined with sufentanyl or tramadol combined with sufentanyl were used respectively. The visual analogue scale （ VAS ） , Brugmann comfort score （BCS） , Ramsay sedative score and side effects were recorded and compared in two groups on 4 h, 8 h, 16 h, 24 h, 48 h after the operation. Results：There was no significant difference in VAS and BCS （ P 〉 0.05 ）. Ramsay score of butorphanol group was significantly higher than those of tramadol group after operation （ P 〈 0. 05 ）. The incidence of dizzy in butorphanol group was higher than tramadol group （ P 〈 0.05 ）. The incidence of postoperative nausea, vomiting （PONV） and pruritus of butorphanol group was significantly lower than those of tramadol group （ P 〈 0.05 ）. Conchlsion： The use of butorphanol or tramador has a good effect of analgesia after epigastrium operation. How choice should depend on the patient condition.

关 键 词：布托啡诺 曲马多 舒芬太尼 术后镇痛 比较 

分 类 号：R614.2[医药卫生—麻醉学]