色谱技术在普萘洛尔对映体药动学研究中的应用进展  

Advances of Chromatography Technology in Study of Propranolol Enantiomers Pharmacokinetics

作　　者：张娟红[1,2] 王荣[1,2] 谢华[1] 孟宪栋[1] 贾正平[1,2] 武晓玉[1] 李文斌[1] 谢希晖[1,2] 

机构地区：[1]兰州军区兰州总医院全军高原损伤防治重点实验室,甘肃兰州730050 [2]兰州大学药学院,甘肃兰州730050

出　　处：《分析测试学报》2012年第6期742-748,共7页Journal of Instrumental Analysis

基　　金：国家科技部重大项目(2008ZXJ-09014-010)

摘　　要：普萘洛尔(PPL)为非选择性β-肾上腺素受体阻滞剂,具有多方面药理作用,临床上使用的普萘洛尔是左旋和右旋异构体的等量混合物。目前已证实普萘洛尔S-型对映体的β受体阻断作用比R-型强约100倍,而R-型具有抗氧化活性,对其手性拆分研究在药理学研究方面有重要意义。该文综述了色谱方法在普萘洛尔对映体拆分方法学及其药动学研究方面的应用,为普萘洛尔质量控制、药动学研究及体内药理学研究提供方法学上的参考。Propranolol （PPL） is a nonselective blocking agent of β-adrenoceptor and it has many pharmacology effects. Propranolol is used clinically as racemics with partes aequales of S- and R-pro- pranolol, but the β-adrenoceptor blocking effects of S- is 100 times more than that of R-propranolol, and the R form is known to have antioxidant activities. It is important in chiral separation for propranolol enantiomers pharmacokinetics. In this paper, the applications of chromatographic method in resolution of propranolol enantiomers and their pharmacokinetics were reviewed by consulting and summarizing references in order to supply a reference for their further exploitation.

关 键 词：色谱 普萘洛尔 对映体 手性拆分 药动学 应用 

分 类 号：O657.7[理学—分析化学] TQ460.72[理学—化学]