内脂素与2型糖尿病及其大血管病变的关系  被引量:2

The correlation of visfatin with type 2 diabetes mellitus and macroangiopathy

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作  者:张丽丽[1] 张晓乾[1] 郭志新[2] 郗光霞 

机构地区:[1]晋城煤业集团总医院内分泌科,048006 [2]山西医科大学第二医院内分泌科 [3]山西大医院内分泌科

出  处:《中国药物与临床》2012年第6期727-729,共3页Chinese Remedies & Clinics

基  金:山西省科技攻关项目(20090311065)

摘  要:目的探讨血浆内脂素(visfatin)与2型糖尿病(T2DM)及其大血管病变的关系。方法 90例T2DM患者,根据是否合并大血管病变分为大血管病变组45例和非大血管病变组45例,另选45名同期健康体检者作为健康对照组。观测所选对象的一般临床指标,用酶联免疫吸附试验(ELISA)测定血浆内脂素水平,并进行统计学分析。结果大血管病变组和非大血管病变组血浆内脂素水平明显高于健康对照组(P<0.01),大血管病变组血浆内脂素水平明显高于非大血管病变组(P<0.01)。两变量简单相关分析显示内脂素水平与体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、收缩压(SBP)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)呈正相关(P<0.05)。多重线性回归分析显示HOMA-IR、WHR、BMI对内脂素的影响有统计学意义。非条件Logistic回归分析示SBP、内脂素为T2DM大血管病变的危险因素。结论血浆内脂素水平增高是T2DM及其大血管病变的危险因素,在T2DM及其大血管病变的发展进程中发挥了重要作用。Objective To explore the correlation of visfatin with type 2 diabetes mellitus (T2DM) and macroangiopathy. Methods According to whether combining with macroangiopathy, 90 T2DM patients were divided into macroangiopathy and non- macroangiopathy groups (n=45 each). In addition, 45 healthy subjects of that period were assigned as control group. All subjects were observed their general clinical parameters. Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma visfatin level. The outcomes were then statistically ana- lyzed. Results Macroangiopathy and non-macroangiopathy groups had a significantly higher level of visfatin than normal control group (P〈0.01). Notably, the plasma visfatin level in macroangiopathy group was obviously higher than that in non-macroangiopathy group (P〈0.01). Two-variate simple correlation analysis showed that plasma level of vislatin was positively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), systolic blood pressure (SBP), fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride (TG) (P〈0.05). Muhiple linear regression showed that HOMA-IR, WHR and BMI affect the level of visfatin. Non-conditional Logistic regression showed that SBP and visfatin were risk factors of macroangiopathy. Conclusion The increased visfatin level was the risk factor of T2DM and macroangiopathy, which exerted major effects on the progression of T2DM and macroangiopathy.

关 键 词:糖尿病2型 糖尿病血管病变 内脂素 

分 类 号:R587.1[医药卫生—内分泌]

 

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