静脉用胺碘酮治疗心衰并发快速房颤的疗效分析  

Intravenous amiodarone in the treatment of heart failure with atrial fibrillation

作　　者：凌云[1] 

机构地区：[1]绵阳市人民医院心血管内科,四川绵阳621000

出　　处：《西部医学》2012年第6期1119-1120,共2页Medical Journal of West China

摘　　要：目的探讨静脉用胺碘酮治疗心衰并发快速房颤的临床疗效。方法选择心衰并发快速房颤患者78例,按入院先后顺序随机分为观察组与对照组,每组39例。观察组给胺碘酮150mg生理盐水稀释后缓慢注射,然后以0.5mg/min维持静滴,24小时总量不超过800mg;对照组先用西地兰0.2mg稀释后缓慢静推,若20分钟无效再给0.2mg,24小时总量不超过1.0mg,两组的常规治疗相同。比较首次用药后不同时刻的心室率变化、24小时后复律情况。结果两组用药后心室率均明显下降,对照组快于观察组,组间差异有统计学意义(P<0.05);观察组有效率高于对照组,组间差异有统计学意义(P<0.05)。结论胺碘酮可有效减慢心衰并发快速房颤的心室率,并使部分房颤患者复律,具有重要临床应用价值。Objective To explore the clinical efficacy of the intravenous amiodarone in the treatment of heart failure with rapid atrial fibrillation. Methods 78 patients with heart failure with rapid atrial fibrillation were included in the study. According to admission order, they were randomly divided into observation group and control group （n=39）. The observation group was given amine block ketone 150mg diluted with normal saline was slowly injected intravenous 0.5mg/min, to maintain total of 24 hours does not exceed 800 mg in the control group were given first Cedilanid 0.2rag diluted slowly after bolus, if 20 minutes is invalid to give 0. 2mg,24 hours total no more than 1.0mg. The ventricular rate at different times after the first drug and 24 hours after cardioversion were observed. Results There were ventricular rate after treatment decreased significantly in the control group faster than the observation group, the difference between the groups was statistically significant （P〈0.05）. The observation group was higher than that in the control group （P〈 0.05）. Conclusion Amiodarone can effectively slow down heart failure complicated by atrial fibrillation, ventricular rate, and some patients with atrial fibrillation cardioversion has important clinical value.

关 键 词：心衰 发快速房颤 胺碘酮 西地兰 治疗应用 

分 类 号：R541.61[医药卫生—心血管疾病]