基质金属蛋白酶-9基因-1562C>T多态性与冠心病易感性的Meta分析  

Polymorphism of matrix metalloproteinase-9 gene-1562c>T and susceptibility of coronary heart disease: a Meta-analysis

作　　者：曹斌[1] 韦育林[1] 刘英梅[1] 吕婉菲[1] 聂如琼[1] 

机构地区：[1]中山大学孙逸仙纪念医院心内科,广州510120

出　　处：《岭南心血管病杂志》2012年第3期257-261,共5页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)基因-1562C>T多态性与冠状动脉粥样硬化性心脏病(coronary artery disease,CAD)易感性的相关性。方法检索中、英文数据库,以得到MMP-9基因-1562C>T多态性与CAD易感性的病例对照研究,应用Meta分析方法对纳入研究结果进行定量合并,采用REVMAN5.0软件进行统计分析。结果共纳入文献18篇,累计病例组9 878例,对照组5 175例,异质性检验P<0.05,I2=69%,合并比值比(odds ratio,OR)=1.34[95%置信区间(confidence interval,CI):1.13～1.59,P<0.001]。其中亚洲人群病例2 461例,对照组2 014例;高加索人群病例7 417例,对照组3 161例。在亚组分析中,亚洲人群、高加索人群OR值分别为1.61(95%CI:1.20～2.15,P<0.01)、1.15(95%CI:0.94～1.40,P>0.05)。结论MMP-9基因-1562C>T多态性可能与亚洲人CAD的易感性相关,而与高加索人群CAD的易感性无关联。Objectives To investigate the association between polymorphism of MMPs-9 gene-1562C〉T and susceptibility of coronary artery disease （CAD）. Methods PubMed, EMBASE and China National Knowledge Infrastructure （CNKI） were searched for published case-control studies investigating the association between MMPs-9 gene-1562C〉T and CAD. Fixed or random effect models were selected for odds ratio （OR） calculation. All statistical analysises were conducted with REVMAN 5.0 software. Results A total of 18 case-control studies involving 9 878 patients and 5 175 controls were analyzed in the study. Alloplastic analysis was significant （P〈0.05,F=69%） , and eomparion of the OR and 95% confidence interval （CI） between the two groups was OR=1.34 （95%CI：1.13-1.59,P〈0.001）. There were 2 461 patients, 2 014 controls in Asian subgroup and 7 417 patients, 3 161 controls in Caucasian subgroup. In the subgroup analysis, OR for Asian and Caucasian populations were 1.61 （95% CI： 1.20-2.15,P〈0.01） and 1.15 （95% CI：0.94- 1.40,P〉0.05） respectively. Conclusions MMP-9 polymorphism （1562C〉T） may be a suseeptibible factor of CAD in Asian population , while it is not associated with CAD in Caucasian population.

关 键 词：冠状动脉疾病 基质金属蛋白酶 基因多态性 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]