钒取代的杂多酸催化一锅四组分Dakin-West反应合成β-乙酰氨基酮(英文)  

One-Pot Four-Component Dakin-West Synthesis of β-Acetamido Ketones Catalyzed by a Vanadium-Substituted Heteropolyacid

作　　者：Reza TAYEBEE Shima TIZABI 

机构地区：[1]Department of Chemistry,School of Sciences,Hakim Sabzevari University

出　　处：《催化学报》2012年第6期923-932,共10页

基　　金：Partial financial support from the Research Council of Sabzevar Tarbiat Moallem University is greatly appreciated

摘　　要：The multicomponent condensation of an aryl aldehyde,acetyl chloride,acetonitrile,and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial,non-corrosive,and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts.The best catalyst was H5PW10V2O40.The methodology used simple experimental conditions,and the short reaction times and high yields indicate it is a useful strategy for the large scale synthesis of β-acetamido ketones.The multicomponent condensation of an aryl aldehyde,acetyl chloride,acetonitrile,and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial,non-corrosive,and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts.The best catalyst was H5PW10V2O40.The methodology used simple experimental conditions,and the short reaction times and high yields indicate it is a useful strategy for the large scale synthesis of β-acetamido ketones.

关 键 词：homogeneous catalysis HETEROPOLYACID KEGGIN WELLS-DAWSON Dakin-West β-acetamido ketone 

分 类 号：O643.32[理学—物理化学]