川乌总碱的抗炎作用  

Anti-inflammatory Effect of Aconitines

作　　者：师海波[1] 周重楚[1] 李延忠[1] 王桂芝[1] 孙英莲[1] 

机构地区：[1]吉林省中医中药研究院中药所,长春130021

出　　处：《中国中药杂志》1990年第3期46-49,共4页China Journal of Chinese Materia Medica

摘　　要：川乌总碱对各种致炎剂如角叉菜胶、蛋清、二甲苯、组胺、五羟色胺的致炎作用,巴豆油气囊肿渗出、肉芽组织增生、白细胞游走、PGE合成均有明显抑制作用;对可逆性被动Arthus反应、大鼠迟发型超敏反应、佐剂关节炎等免疫性炎症也有显著抑制作用,还有明显的镇痛作用。Aconitines are the total alkaloids isolated from the main root of Aconitum carmichaeli. They have marked suppressive effect on the swelling of rat's hind paw induced by injections of fresh egg protein, carrageenin, histamine and 5-HT, on the mouse's ear oedema induced by bimethylphenyl, ou the exudate and proliferation of granulation tissue of granuloma pouch induced by croton oil, on the leukocyte migration and on the c ntents of PGE in the exudate of the swelling hind paw induced by injecting carrageenin. Aconitines have been found useful in inhibiting significantly such immune inflammations as reversible passive Arthus reaction, rat's delayed skin hypersensitivity and adjuvant arthritis. They have also a noticeable analgesic effect.

关 键 词：川乌总碱 抗炎剂 炎症介质 

分 类 号：R285.6[医药卫生—中药学]