晕复静抑制大白鼠及自愿者前庭刺激反应的研究  

Studies on the Inhibitory Effect of Yunfujing on Vestibular Stimulative Response in Rats and Volunteers

作　　者：邓夕军[1] 张均田[2] 石成璋 安定一[3] 

机构地区：[1]解放军第86医院,243100 [2]中国医学科学院药物研究所,北京100050 [3]解放军空军总医院,北京100036

出　　处：《中国中药杂志》1990年第4期48-49,共2页China Journal of Chinese Materia Medica

摘　　要：取50只雌性大鼠用于旋转试验,晕复静可有效地抑制眼球震颤,其作用强度比密环菌强20～30倍;采用Coriolis试验观察了32名自愿者,口服晕复静400mg后,接受前庭刺激的耐受时间明显延长,服药前后的平均耐受时间分别为411.34秒和759.63秒;与此同时,血压、脉搏无明显影响。Fifty female rats were used in the experiment. With rotation model, Yunfujing was shown to inhibit nystagmic response of rats. The inhibitory effect was 20～30 times stronger than that of Mihuanjun. In Coriolis test, the tolerance time of vestibular stimulative response was taken as a parameter for judging drug efficacy in 32 male volunteers. Following oral administration of Yunfujing at a dose of 400mg, the tolerance time of vestibular stimulative response was prolonged significantly from 411.34 to 759.63s. In the mean time, no changes of blood pressure and pulse were observed in the treated group.

关 键 词：晕复静 眼球震颤 前庭刺激反应 

分 类 号：R286[医药卫生—中药学]