复方苦豆子对肾性高血压复合高脂血症大鼠血浆内皮素和一氧化氮合成酶的影响  

Effects of Compound KuDouZi on endothelin and nitric oxide synthase in plasma in renal hypertension combined hyperlipidemia rats

作　　者：刘晓敏[1] 陈虹[2] 

机构地区：[1]吉林医药学院附属医院,吉林吉林132013 [2]石河子大学药学院药理学系省部共建新疆特种植物药资源教育部重点实验室

出　　处：《山东医药》2012年第20期19-21,24,共4页Shandong Medical Journal

基　　金：新疆生产建设兵团医药专项(04GG24)

摘　　要：目的研究复方苦豆子(CK)对肾性高血压复合高脂血症大鼠血压、体质量、肝脏脂质、血浆内皮素(ET)、总一氧化氮合成酶(T-NOS)及结构型一氧化氮合成酶(cNOS)的影响。方法建立二肾一夹(2K1C)肾性高血压复合高脂血症大鼠模型。随机分为5组,模型组;CK高、中、低剂量组;阳性对照组;每组12只。每天灌胃脂肪乳的同时,给予不同的干预措施,连续8周。另取10只为假手术组。给药前及给药1、2、4、8周观察大鼠体质量变化;给药8周测大鼠尾动脉收缩压及心率;检测大鼠ET、T-NOS和cNOS;肝脏脂质(TC、TG)。结果用药2周后,模型组大鼠体质量呈下降趋势,状态较差;各给药组大鼠体质量与模型组比较有所升高,用药4周后升高明显(P<0.05),状态良好;给药8周后,中、高剂量与模型组相比血压明显下降、明显降低血浆ET、肝匀浆中的TC和TG含量、升高T-NOS和cNOS含量(P<0.01)。结论 CK可降低高血压复合高脂血症模型大鼠的血压,调节肝脏脂质,并推测其降压调脂作用机制与内皮系统的调节有关。Objective To study the effects of Compound KuDouZi（CK） on blood pressure,body weight,liver lipids,plasma endothelin（ET）,nitric oxide synthase in renal hypertension combined hyperlipidemia rats.Methods To establish two kidney one clip（2K1C） renal hypertension rat compound hyperlipidemia model.The successful model of rats were randomly divided into 5 groups and given different interventions for 8 weeks： the model group;CK high,medium and low dose group;positive control group.Another 10 rats for the sham group.Observed the rats body weight changes at 0 week,1 week,2 weeks,4 weeks,8 weeks.When the experience were over,systolic blood pressure,heart rate and plasma ET,total nitric oxide synthase and nitric oxide synthase（T-NOS and cNOS）,liver lipid（TC,TG） were measured.Results After 2 weeks,the rats body weight decreased and the state was poor,weight of the drug-treated rats increased compared with model group,after 4 weeks of treatment increased significantly（P〈0.05）.When the experience were over,in middle-dose and high-dose group blood pressure decreased significantly（P〈0.01）,the plasma levels of ET reduced（P〈0.01）,NOS levels increased（P〈0.01）,and liver homogenate TC,TG content were lower（P〈0.01）.Conclusion CK can reduce blood pressure and regulate blood lipids in high blood pressure compound hyperlipidemia rats,the mechanism of CK may be related to endothelial system conditioning.

关 键 词：复方苦豆子 高血压复合高脂血症 血压 血脂 内皮素 一氧化氮合成酶 

分 类 号：R544.1[医药卫生—心血管疾病]