JWA T723G多态性与胃癌易感性  

The relationship between JWA T723G polymorphism and the risk of gastric cancer

作　　者：王卓[1] 高长明[1] 吴建中[1] 丁建华[1] 李苏平[1] 马蓉[1] 王洁[1] 刘燕婷[1] 曹海霞[1] 

机构地区：[1]江苏省肿瘤防治研究所流行病研究室,江苏南京210009

出　　处：《中国肿瘤外科杂志》2012年第3期148-150,共3页Chinese Journal of Surgical Oncology

基　　金：江苏省肿瘤防治研究所院青年基金(ZQ200404)

摘　　要：目的探讨JWAT723G多态性与胃癌易感性之间的关系。方法采用多聚酶链反应(polymerase chain reaction,PCR)和变性高效液相色谱法(denaturing high performance liquid chromatography,DHPLC)检测107例胃癌患者和200例同龄健康人群的JWAT723G多态性并进行分析。结果病例组和对照组JWAT723G基因分布频度无显著差异(χ2=2.290,P=0.318)。在调整了性别和年龄后,与T/T基因型相比,T/G基因型发生胃癌的危险性上升到1.21(95%CI:0.94～1.57),G/G基因型发生胃癌的危险性上升到1.49(95%CI:0.45～4.96)。合并T/G和G/G基因型分析显示G等位基因发生胃癌的危险性上升到1.21(95%CI:0.95～1.55),JWAT723G多态性与胃癌的易感性无相关性(P=0.1316)。结论 JWAT723G多态性与胃癌易感性不相关。Objective To investigate the association between JWA T723G polymorphisms and the risk of gastric cancer. Methods We conducted a case-control study of 107 cases of gastric cancer and population-based 200 controls in Jiangsu province, China. JWA T723G genotypes were identified by PCR and denaturing high performance liquid chromatography （DHPLC）. Logistic regression was used to calculated odds ratios （OR） and 95% confidence intervals （95% CI）. Results The frequencies ofJWA T723G showed no significant difference between cases and controls （χ2 =2. 290, P =0. 318）. Relative to JWA 723 T/T genotype, the age and sex adjusted OR for T/G was 1.21 （95% CI： O. 94 - 1.57）, the adjusted OR for G/G was 1.49 （95% CI： 0.45 -4.96） , and the adjusted OR for G allele was 1.21 （95%CI： 0.95 -1.55）. The JWA 723 G allele showed no moderately increased risk for gastric cancer （P = 0.1316）. Conclusions There is no association between the JWA T723G polymorphisms and gastric cancer susceptibility.

关 键 词：胃癌易感性 JWAT723G多态性 病例对照研究 

分 类 号：R735.2[医药卫生—肿瘤]