慢加急性肝衰竭患者HBV-DNA变化模式与其预后的关系  

The Relationship Between the Changing Profile of HBV-DNA and Outcome of Patients with Acute-on-Chronic Liver Failure

作　　者：张鹤[1] 杨玲[1] 曾文铤[1] 梁建新[1] 谢栩硕[1] 

机构地区：[1]广州医学院第一附属医院感染内科,广州510120

出　　处：《中外医疗》2012年第13期22-23,共2页China & Foreign Medical Treatment

摘　　要：目的探讨HBV-DNA动态变化对慢加急性肝功能衰竭预后的影响。方法对我科2006年6月至2011年6月收治的53例乙肝相关性慢加急性肝衰竭患者进行回顾性分析,根据治疗结果将患者分为存活组与死亡组。分析2组患者发病前、治疗初HBV-DNA及其变化等。结果发病前及治疗初期单一时间点HBV-DNA与预后关系不大(P>0.05)。HBV-DNA升高或降低>2log在存活组所占比率明显低于死亡组,HBV-DNA维持不变或变化<2log存活组则明显高于死亡组,统计学分析表明上述改变模式在2组间的差异有统计学意义(P<0.05)。结论 HBV-DNA明显下降或升高均不利于预后,而HBV-DNA维持不变或变化<2log预后较好。Objective To investigate whether HBV viral factors correlate with the prognosis in patients with acute--on--chronic liver failure （ACLF）.Methods A retrospective study was carried out on the 53 patients with HBV-ACLF treated in our department from Jun.2006 to Jun.2011.Serum HBV-DNA levels at the onset of treatment and before the onset were determined,and their correlation with the outcomes of patients was explored. Results Although there was no significant difference in HBV DNA levels on admission or before the onset between the survival group and the death ones=The HBV--DNA decreased or increased than 2log was much more in patients who died than in those who recovered,The HBV--DNA decrease less than 2log or keeping stable in viral load was much more in patients who recovered than in those who died,There were significant difference in the Changing Profile between the two groups（P〈0.05）.Conclusion The decrease much more in viral load was associated with mortality of the patients with HBV--ACLF, and the decrease less than 2log or keeping stable implicated the recovery of the ACLF patients.

关 键 词：慢加急性肝衰竭 HBV-DNA定量 预后 

分 类 号：R512.62[医药卫生—内科学]