SD大鼠脏器重量及脏器系数正常参考值的确立与应用  

Establishment and application of the normal reference values of organ masses and organ/body coefficients in SD rats

作　　者：董延生[1] 尹纪业[1] 陈长 瞿文生[1] 袁本利[1] 高晓新[1] 丁日高[1] 王和枚[1] 

机构地区：[1]军事医学科学院毒物药物研究所,国家北京药物安全评价研究中心,北京100850 [2]总装备部后勤部航天城门诊部,北京100094

出　　处：《军事医学》2012年第5期351-353,共3页Military Medical Sciences

基　　金：国家科技重大专项资助项目(2008ZX09305-003;2010ZXJ0900X-005)

摘　　要：目的确定本中心不同周龄SD大鼠脏器重量与脏器系数的正常参考值范围,为药物安全性评价与研究提供重要参考数据。方法以本中心近7年开展的SD大鼠长期毒性实验中空白对照组动物为数据来源,分为8～12、12～24及24～36周龄3个年龄段,每年龄段包括雌性、雄性大鼠各200只,分别统计各年龄段雌性、雄性动物的脑、心脏、肺脏、肝脏、脾脏、肾脏、肾上腺、胸腺、睾丸、附睾、卵巢与子宫等脏器重量与脏器系数,以95%可信区间作为正常参考值范围。结果与结论本中心8～12、12～24及24～36不同周龄SD大鼠脑、心脏、肺脏、肝脏、脾脏、肾脏、肾上腺、胸腺、睾丸、附睾、卵巢与子宫等脏器重量及脏器系数的正常参考值范围与其他实验室报道的结果可比性良好。Objective To establish the normal reference values of the mass and coefficients of main organs of SD rats in order to provide important background data for National Beijing Center for Drug Safety Evaluation and Research （ NBCDS- ER）. Method This study involved 1200 SD rats from the control groups of the repeated dosing toxicity tests conducted at NBCDSER in the past seven years, aged 8 to 12, 12 to 24 and 24 to 36 weeks, with males and females in half. The mass and coefficients of the brain, heart, lung, liver, spleen, kidney, adrenal gland, thymus, testis, epididymis, ovary and uterus were statistically analyzed. The normal reference values were set at x± 1.96SD. Results and Conclusion The nor- mal reference values of organ masses and coefficients in SD rats in NBCDSER are comparable to the data from other labora- tories in China.

关 键 词：SD大鼠 脏器重量 脏器系数 正常参考值 器官测量 

分 类 号：R99[医药卫生—毒理学]