促吞噬肽衍生物T肽抑制小鼠移植瘤和术后残瘤生长的药效学研究  

Evaluation of inhibition effects of T peptide on postsurgical residual tumor growth

作　　者：汪琼[1] 贾娜[1] 杨德宣[1] 王珊珊[1] 郭万军[1] 袁守军[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《军事医学》2012年第5期357-361,共5页Military Medical Sciences

基　　金：国家自然科学基金资助项目(30973564);国家科技重大专项资助项目(2009ZX09301-002)

摘　　要：目的研究免疫增强剂促吞噬肽(tuftsin)衍生物T肽对小鼠皮下移植瘤以及移植瘤术后残瘤生长的抑制作用。方法建立S180肉瘤、B16-BL6黑色素瘤小鼠皮下移植瘤模型以及S180肉瘤、Lewis肺癌术后残瘤模型,观察T肽给药后肿瘤的生长情况,研究T肽的抗癌作用。结果 T肽对S180肉瘤皮下移植瘤有一定的抑制效果,按照肿瘤体积得出的抑制率范围为37.0%～48.1%,按照瘤重得出的抑制率范围为12.1%～40.9%;对B16-BL6黑色素瘤小鼠皮下移植瘤的生长基本没有抑制作用。对小鼠术后残瘤生长T肽表现出良好的抑制效果,按照肿瘤体积得出的抑制率范围为59.9%～78.8%,按照瘤重得出的抑制率为64.4%～79.6%,对小鼠未观察到毒副作用。结论 T肽明显抑制小鼠术后残瘤的生长,毒副作用小,预示着T肽有潜力成为防治术后残瘤生长和转移的抗癌新药。Obiective To study the pharmacodynamic effects of a derivative of tuftsin T peptide on non-surgery and sur- gery residual tumors in a mouse xenograft tumour model. Methods Two mouse models of subcutaneous transplanted tumor and surgery residual tumor were established. The inhibitory effect of T peptide on surgery residual tumors and non-surgery tumors was preliminarily studied. Results The growth of non-surgery residual mouse tumors of S180 sarcoma was inhibited by T peptide. The inhibitory rate reached 48.1% according to the tumor volume and 40.9% according to the inhibitory rate of tumor weight. T peptide had no effect on B16-BL6 melanoma xenografts. In another model of postsurgery residual tumors, T peptide produced strong inhibitory effect with tumor volume inhibitory rates ranging from 59.9% to 78.8% and tumor weight suppression rates from 64.4% to 79.6%. Conclusion T peptide has inhibitory effect on postsurgery residual tumors in mice without observable toxicity and side effect, and may have the potential for development and clinical applica- tion.

关 键 词：生物反应调节剂 T肽 促吞噬肽 术后残瘤模型 

分 类 号：R96[医药卫生—药理学]