仿生提取-电感耦合等离子体质谱法测定含朱砂中药制剂中可溶性汞含量  

Determination of leachable mercury in Chinese traditional patent medicine containing cinnabar by bionic extraction-ICP-MS

作　　者：陈秋生[1,2] 程奕[1,2] 孟兆芳[1,2] 张强[1] 刘烨潼[1] 张玺[1] 

机构地区：[1]天津市农业科学院中心实验室,天津300381 [2]天津海世达检测技术有限公司,天津300381

出　　处：《药物分析杂志》2012年第6期1036-1039,1047,共5页Chinese Journal of Pharmaceutical Analysis

基　　金：国家支撑计划子课题(2006BAI06A01-04);中药中重金属及农药残留检测技术研究;天津市农科院院长基金项目(08014);含矿物药中药制剂中砷;汞元素形态分析检测技术的研究

摘　　要：目的:建立仿生提取-电感耦合等离子体质谱技术(ICP-MS)测定含朱砂中药制剂中可溶性汞含量的分析测定方法。方法:通过模拟人体胃肠道环境,采用人工胃液提取含朱砂中药制剂中的可溶性汞,结合ICP-MS进行分析测定。结果:该方法操作简便、灵敏。方法回收率为98.8%,检出限为0.20μg.L-1,重复性良好(RSD=4.1%)。结论:通过对实际样品的测定,该方法可用于含朱砂中药制剂中可溶性汞含量的测定。Objective：To establish a method for determination of the leachable mercury in Chinese traditional patent medicine containing cinnabar by bionic extraction-ICP-MS.Method：Through simulating stomach condition,the leachable mercury was extracted by artificial gastric juice and detected by ICP-MS.Result：The method was simple,sensitive,accurate,and the mean recovery was 98.8%,the detection limit was 0.20 μg·L-1,the precision was calculated of 4.1%（RSD）.Conclusion：The developed method is simple,sensitive,accurate,and was suitable for the determination of leachable mercury in Chinese traditional patent medicine containing cinnabar.

关 键 词：可溶性汞 朱砂 仿生提取 电感耦合等离子体质谱 含量测定 

分 类 号：R917[医药卫生—药物分析学]