急性白血病患者凝血与纤溶指标的变化  

Change of Blood Clotting and Fibrolysis Data for Acute Leukemia

作　　者：罗建伟[1] 李亚红[1] 陈凤如[1] 

机构地区：[1]广东省佛山市顺德区第一人民医院检验科,广东佛山528300

出　　处：《黑龙江医学》2012年第3期168-169,191,共3页Heilongjiang Medical Journal

摘　　要：目的观察急性白血病(AL)患者凝血与纤溶指标的变化,以探索其在急性白血病诊断、治疗及预后判断中的意义。方法采用Sysmex CA-1500全自动血凝仪检测了30例初诊AL患者的血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白(原)降解产物(FDPs)、血浆D-二聚体(D-Dimer)及纤维蛋白原定量(FIB),并对其结果进行分析。结果急性白血病组PT、APTT与正常对照组结果无显著性差异(P>0.05),而急性白血病组的FDPs与D-Dimer明显增高,FIB明显降低,与正常对照组比较均有显著差异(P均<0.05)。结论急性白血病患者处于纤溶亢进状态或有出血倾向,FDPs、D-Dimer与FIB的动态监测对急性白血病出血的诊断以及预后判断,有重要的临床意义。Objective To observe the BC and fibrolysis of AL patient and discuss the diagnosis, treatment and prognosis. Methods The PT, AVIT, FDP, D -Dimer and FIB of 30 cases were detected with Sysmex CA - 1500, the results were analyzed. Results The PT and AIrIT in both group had no difference. The FDP and D - Dimer were increased and FIB decreased in AL group compared with normal P 〈 0.05. Conclusion The AL pa- tient might have tendency of hyperfibrolysis and bleeding. The observing of FDPs ,D -Dimer and FIB might obtain diagnosis and predict the prognosis.

关 键 词：急性白血病 血浆纤维蛋白原降解产物 血浆D-二聚体 

分 类 号：R446.1[医药卫生—诊断学]