A Facile Synthesis of Enantiomerically Pure （R）-6-Arylbinols  

作　　者：王文伶 龙玉华 邹志富 杨定乔 

机构地区：[1]School of Chemistry and Environment,South China Normal University,Guangzhou,Guangdong 510006,China

出　　处：《Chinese Journal of Chemistry》2012年第5期1092-1096,共5页中国化学（英文版）

摘　　要：This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield （up to 73%）. On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis.This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2＇-dihydroxy-1, l＇- binaphthyl derivatives starting from the commercially available （R）-2,2＇-hydroxy-l, l＇-binaphthyl [（R）-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield （up to 73%）. On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis.

关 键 词：（R）-1 1＇-bi-2-naphthols derivatives Suzuki cross coupling reaction chiral auxiliary SYNTHESIS 

分 类 号：O626.11[理学—有机化学] O753.2[理学—化学]