Synthesis and Cyclization of 8-Formyl-2-（phenoxymethyl）- quinoline-3-carboxylic Acids  

作　　者：高文涛 赵治刚 李阳 闫岩 李凤 

机构地区：[1]Institute of Superfine Chemicals,Bohai University,Jinzhou,Liaoning 121000,China

出　　处：《Chinese Journal of Chemistry》2012年第5期1127-1132,共6页中国化学（英文版）

摘　　要：A facile synthesis of a series of new quinoline-8-carbaldehyde compounds, namely 8-formyl-2- （phenoxymethyl）quinoline-3-carboxylic acids （4a--4h） and 13-oxo-6,13-dihydro[1]benzoxepino[3,4-b]quinoline- 8-carbaldehyde （5a--5g） is described, involving the one-pot synthesis reaction of ethyl 2-（chloromethyl）-8- formylquinoline-3-carboxylate （3） with substituted phenols followed by the intramolecular cyclization reaction via the treatment with polyphosphoric acid （PPA）. Quinoline-8-carbaldehydes 4a--4h and 5a--5g are novel and their structures were supported by IR, IH NMR, 13C NMR, MS and elemental analysis.A facile synthesis of a series of new quinoline-8-carbaldehyde compounds, namely 8-formyl-2- （phenoxymethyl）quinoline-3-carboxylic acids （4a--4h） and 13-oxo-6,13-dihydro[1]benzoxepino[3,4-b]quinoline- 8-carbaldehyde （5a--5g） is described, involving the one-pot synthesis reaction of ethyl 2-（chloromethyl）-8- formylquinoline-3-carboxylate （3） with substituted phenols followed by the intramolecular cyclization reaction via the treatment with polyphosphoric acid （PPA）. Quinoline-8-carbaldehydes 4a--4h and 5a--5g are novel and their structures were supported by IR, IH NMR, 13C NMR, MS and elemental analysis.

关 键 词：benzoxepinoquinoline quinoline-8-carbaldehyde ONE-POT polyphosphoric acid （PPA） cyclization reaction 

分 类 号：TQ645[化学工程—精细化工] TQ655