脂肪干细胞在皮肤创伤修复中的研究进展与应用前景  

Research progresses and applications outlook of adipose-derived stem cells in skin wound healing

作　　者：傅士博[1] 王雪[1] 温从吉[1] 王丹茹[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,200011

出　　处：《中华损伤与修复杂志（电子版）》2012年第1期63-66,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：上海市科委浦江人才计划(10PJD008)

摘　　要：脂肪干细胞是存在于脂肪组织中的一种多能干细胞,属成体干细胞,现已证实其向多种中胚层来源组织分化的潜能。其分化能力可用于修复缺损,而旁分泌功能则可调节周围组织功能。在骨、软组织、血管和神经修复领域中开展了大量临床前研究和初步的临床试验。本文主要介绍脂肪干细胞在皮肤创伤修复中的最新研究进展并对该技术在未来大量应用中可能出现的危险进行初步讨论。Adipose-derived stem cells（ADSCs） are a progenitor cell population residing in adipose tissue. They are mesodermal originated adult stem cells and their multipotent differentiation capability to many kinds of mesodermal tissue is well profiled. The differentiation capability helps the wound healing and the feature of paracrine regulates the function of surrounding tissue. A great number of preclinical studies and primary clinical studies are undergoing in bone, soft tissue, vessel and nerve repair. The authors intend to present the latest research progresses in skin wound repair and initially discuss the potential danger in massive application that may appear in future.

关 键 词：脂肪干细胞 创伤修复 生物支架 细胞因子 瘢痕 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]