不稳定性心绞痛患者调脂干预对C反应蛋白的影响  

Effect of atorvastatin on high sensitive C-reactive protein in patients with unstable angina

作　　者：廖志坚[1] 林泽鹏[2] 陈玲[3] 

机构地区：[1]深圳市孙逸仙心血管医院药剂科,518020 [2]深圳市孙逸仙心血管医院门急诊,518020 [3]深圳市人民医院二门诊部

出　　处：《中国实用医药》2012年第13期46-47,共2页China Practical Medicine

摘　　要：目的探讨阿托伐他汀对不稳定性心绞痛(UA)患者血浆高敏C-反应蛋白(hs-CRP)的影响。方法测定60例不稳定性心绞痛患者在常规治疗基础上口服阿托伐他汀(商品名立普妥)20mg,治疗12个月前后血浆hs-CRP。结果 60例不稳定性心绞痛患者经阿托伐他汀治疗12个月后血浆hs-CRP显著下降(P<0.01)。结论阿托伐他汀对不稳定性心绞痛患者减少炎症反应起着重要的作用。Objective To observe the influence of atorvastatin on serum high sensitive C-reactive pro- tein （hs-CRP） levels in patients with unstable angina. Methods Sixty subjects with arteriosclerosis plaque of coronary artery were given atorvastatin 20 mg qd for 12 months. The serum levels of hs-CRP were detected before and 12 months after treatment in all patients with helical computerized tomography. Results After 12 months administration of atorvastatin, the serum levels of hs-CRP was reduced （P 〈 0. 01 ）. Condusion Atorvastatin decreased inflammatory reaction in patients with unstable angina,which may improve stabiliation of the plaque in coronary artery.

关 键 词：冠心病 脂类和降脂药 高敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]